DOF和DCF方案治疗进展期胃癌的疗效分析.pdfVIP

594 Journal of Medical Science in Central South China,Nov.2012,Vol.40,No.6 文章编号:2095-1116(2012)06-0594-03 ·临床医学· DOF和 DCF方案治疗进展期胃癌的疗效分析 1 韩守恒 ,戴文香,伍尤华 (南华大学附属第一医院肿瘤内科,湖南衡阳421001) 摘摇 要:摇 目的摇 分析比较多西他赛联合奥沙利铂、氟尿嘧啶(DOF方案)与联合顺铂、氟尿嘧啶(DCF方案) 治疗进展期胃癌(Advanced gastric cancer)患者的初步疗效和患者的耐受性。 摇 方法摇 75例晚期胃癌患者,分别接 受DOF方案或DCF方案治疗,DOF组37例,DCF组38例。 两组患者特征具有可比性(P ﹥0.05)。 摇 结果摇 两组 均有35例可以评价疗效。 DOF组有效率为45.71%(16/ 35),其中CR2例;DCF组有效率为42.86%(15/ 35),其 中CR 1例。 DOF组中位无进展时间为5.6 月,DCF组中位无进展时间为5.8 月。 DOF组中位生存期9.5 月;DCF 组中位生存期9.7 月。 两组毒性反应主要为骨髓抑制,胃肠道反应,肾毒性和神经毒性。 摇 结论摇 DOF 方案和 DCF方案治疗进展期胃癌疗效相似,但DOF方案比DCF方案的耐受性要好。 关键词:摇 进展期胃癌;摇 多西他赛;摇 奥沙利铂;摇 顺铂;摇 氟尿嘧啶 中图分类号:R735郾2摇 摇 摇 文献标识码:A A Comparative Study of DOF Regimen and DCF Regimen for Advanced gastric Cancer HAN Shouheng,DAI Wenxiang,WU Youhua (FirstAffiliated Hospital,University of South China,Hengyang 421001,China) Abstract:摇 Objective摇 The efficacy and toxicity of docetaxel plus oxaliplatin andfluorouracil regimen and docetaxel plus cisplatin andfluorouracil regimen in the treatment of the cases with advanced gastric cancer were observed and com鄄 pared.摇 Methods摇 The total of75 caseswere enrolled in the investigation,37 cases received DOF regimen and 38 cases received DCFregimen.Twogroupswerewell鄄matchedwithbaselinediseasecharacteristics(P ﹥0.05).摇 Results摇 35 ca鄄 ses can be evaluated in DOF and DCF regimens respectively.In DOF group,the response rate was45.71%(16/ 35),2 a鄄 chieved complete response (CR);In DCF group,the response rate was 42.86% (15/ 35),2 achieved complete response (CR).The median time鄄to鄄p