OPN、ER和CK19在甲状腺乳头状癌诊断中的作用.docVIP

OPN、ER和CK19在甲状腺乳头状癌中的表达及临床意义 吕小元1，易德保1，阳海红2 （1、邵阳医学高等专科学校 湖南邵阳 422000 2、邵阳市中心医院 湖南邵阳 422000） 摘要： 目的 探讨OPN、ER和CK19在甲状腺乳头状癌的表达及在鉴别诊断中的应用。 方法 应用免疫组化S-P法对80例甲状腺癌，50例甲状腺腺瘤，50例瘤旁甲状腺组织进行OPN,ER和CK19检测。结果 甲状腺乳头状癌组织OPN、ER和CK19的阳性表达率分别为83.3%、74.1%和96.3%，甲状腺腺瘤组织中三者阳性表达率分别为10.0%，30.0%，24.0%，在正常甲状腺组织中三者阳性表达率分别为4.0%，6.0%，4.0%，OPN、ER和CK19在甲状腺乳头状癌组织中的阳性表达率明显高于甲状腺腺瘤组织和正常甲状腺组织,它们之间有显著性差异（P0.05）. 结论 OPN、ER和CK19在甲状腺乳头状癌的病理诊断和鉴别诊断中具有重要意义和临床实用价值。 关键词： 甲状腺乳头状癌；骨桥蛋白；雌激素受体；角蛋白；鉴别诊断 Expression of osteopontin,estrogen receptor and cytokeratin19 in papillary thyroid carcinoma and their clinical significance LV Xiao-yuan1 ,YI De-bao1, YANG Hai-hong2 1、Shaoyang medicine college level specialty school Hunan Shaoyang 422000 2、The center hospital of Hunan shaoyang Hunan Shaoyang 422000 [Abstract]Objective To study the expression of osteopontin,estrogen receptor and cytokeratin19 in papillary thyroid carcinoma and their differential diagnostic application.Methods OPN,ER and CK19 in 80 cases of thyroid carcinoma ,50 cases of adinoma and 50 cases of adjacent nomal tissues of thyroid tumor were exmined using the method of immunohistochemistry S-P.Results The thyroid gland papilliform tumor organizes OPN, ER and the CK19masculine expression rate respectively is 83.3%, 74.1% and 96.3%, in the tyroma organization respectively is 10.0%,30.0%,24.0%, in the normal thyroid gland organization respectively is 4.0%,6.0%,4.0%,OPN, ER and CK19 organize at the thyroid gland papilliform tumor the masculine expression rate to be higher than the tyroma organization and the normal thyroid gland organization obviously.Between them the difference has the significance (P0.05) Conclusions OPN,ER and CK19 can be important molecular markers for diagnosing papillary thyroid carcinoma Key words：Papillarythyroidcarcinoma;Osteopontin;Estrogenreceptor;Cytokeratin; Differential diagnosis [作者简介]吕小元（1977-），女，大学本科，讲