高血压患者血清胱抑素C与冠心病的关系.docVIP

高血压患者血清胱抑素C与冠心病的关系 【摘要】 目的 探讨高血压患者血清胱抑素C(Cys C)与冠心病的相关性。方法 行冠脉造影检查的115例高血压患者，根据结果分为高血压冠心病组(66例)和高血压冠状动脉粥样硬化组(49例)，检测血清脂蛋白a、载脂蛋白A、载脂蛋白B、高密度脂蛋白、低密度脂蛋白、三酰甘油、胆固醇、血肌酐、Cys C等。分析冠心病与Cys C的相关性，并用二元Logistic回归方法分析Cys C、糖尿病、性别、年龄、身高、体重及IBM等因素与冠心病之间的相关性。结果 高血压合并冠心病组Cys C含量明显高于冠状动脉粥样硬化组(Plt;0.001)，应用二元Logistic回归方法进行分析，发现Cys C、脂蛋白a、载脂蛋白A、载脂蛋白B、高密度脂蛋白、低密度脂蛋白、三酰甘油、胆固醇、糖尿病、性别、年龄、体重指数与冠心病相关。结论 Cys C是高血压患者发生冠心病的独立危险因素，与血管的病变程度有正相关性，检测Cys C是预测冠心病发病的有意义的指标。 【关键词】 血清胱抑素C;冠心病;高血压 　　[Abstract] Objective To study correlation of serum cystain C (Cys C) and coronary heart disease in hypertension patients. Methods A total of 115 hypertension patient with the do coronary angiography inspection were divided into the hypertension and coronary disease group (66 cases) and the hypertension and coronary artherosclerosis group (49 ones) for the determination of serum lipoprotein A, apolipoprotein A, apolipoprotein B, high-density lipoprotein, low-density lipoprotein, triacylglycerol, cholesterol, creatinine, and Cys C. The correlation between coronary heart disease, and each of Cys C, diabetes, gender, age, height, body weight, and IBM was analyzed, respectively, by binary Logistic regression. Results The Cys C contents for the hypertension plus coronary heart disease group are significantly higher than those for the coronary atherosclerosis group (Plt;0.001). There is the positive correlation between coronary heart disease, and each of Cys C, diabetes, gender, age, height, body weight, and IBM.Conclusion Serum Cys C is an independent risk factor the hypertension patient suffering for coronary heart disease, and has the positive correlation with the degree of vascular lesions. Serum Cys C is a good index for predicting coronary heart disease. 　　[Key words] serum cystain C; coronary heart disease; hypertension 　　长期以来胱抑素C(Cys C)是仅用来评价肾功能损伤的一项敏感指标，可是近年来的研究发现胱抑素C与动脉粥样硬化包括冠心病的发生、发展、病变程度以及预后有明确的相关性，这种相关性与肾性方面胱抑素C生物学是不一样的[1]。为了解血清胱抑素C水平与冠心病患者的关系，对本院最近3个月115例行冠脉造影检查的高血压患者行Cys C测定，同时测脂蛋白a、载脂蛋白A、载