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Ministry of Health People’s Republic of China Page * 中华人民共和国卫生部 / Ministry of Health People’s Republic of China Page * 中华人民共和国卫生部 Ministry of Health People’s Republic of China Ministry of Health People’s Republic of China Ministry of Health People’s Republic of China / Ministry of Health People’s Republic of China Page * 中华人民共和国卫生部 / Ministry of Health People’s Republic of China Page * 中华人民共和国卫生部 * Antibiotics are often used in wrong doses, for too long, and with too broad a spectrum of antimicrobial activity. Antimicrobial resistance, superinfection and unnecessary costs are common consequences of inappropriate surgical antibiotic prophylaxis. Hence, rational use of antibiotics is essential. World Health Assembly urged WHO Member States to formulate measures to encourage appropriate and cost-effective use of medicines. The Chinese Ministry set series of regulations and rules, improving the use of medicines, especially antibiotics. To monitor the volume and patterns of antibiotic use and the impact of control measures, a National Monitoring Network on Clinical Antibiotics Use (Network) was established in China in 2005. The network has been regularly collecting antibiotic use data from 120 tertiary general hospitals around the country. The monitoring report from 2006 to 2007 showed that the proportion of irrational antibiotic use in surgical practice was widespread and serious. With the support of WHO, the Ministry of Health initiated an intervention project to promote rational antibiotic prophylaxis in clean surgeries from 2008 to 2009. 2.1. Hospital sampling The study was conducted in 176 tertiary hospitals in China totally. The sampling frame is within the Network which consists of 164 tertiary hospitals as control group (CG). A total of 12 tertiary general hospitals were included in intervention group (IG). 2.2. Target surgeries Thyroidectomy Mastectomy Hernia 2.3. Baseline survey and evaluation of rationality Hospitals in IG
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