【化学工程与工艺专业】【毕业设计+开题报告+文献综述】3-氨基异烟酸的合成.doc

（20 届） 毕业设计 3-氨基异烟酸的合成 摘要: 3-氨基异烟酸是一种重要的化工中间体。本文研究了以异喹啉为起始原料，经氧化开环生成3,4-吡啶二甲酸，然后在乙酸酐作用下分子内脱水得到3，4-吡啶二甲酰亚胺，最后经霍夫曼降解生成目标产物3-氨基异烟酸，总收率为52.67%，并对目标产物进行了熔点和核磁氢谱表征。 关键词: 3-氨基异烟酸合成霍夫曼降解Abstract: 3-aminoisonicotinic acid is an kind of important chemical intermediates. In this paper 3-aminoisonicotinic acid was synthesized from isoquinoline as raw material, through an xidative cleavage of isoquinoline to attain pyridine-3,4-dicarboxylic acid, then intramolecular dehydration under the action of acetic anhydride reduction to attain 3,4-Pyridinedicarbimide, finally Hofmann degradation to generate the target product , the total yield was 52.67%. In addition, its structures has been determined by melt point and 1HNMR data. Key words: 3 - Aminoisonicotinic acid; Synthesis; Hofmann degradation 目 录 摘要 I Abstract:. II 1 绪论 1 1.1 异烟酸的合成及其研究 ..........................................................................................................1 1.1.1 异烟酸的制备方法 ........................................................................................................1 1.1.2 应用研究 ........................................................................................................................3 1.2 3-氨基异烟酸的结构及特点 .....................................................................................................4 1.3 本文课题的提出及研究方法 1.3.1.课题研究内容 1.3.2合成路线的选择 4 1.3.3合成路线的难点 2 实验部分 2.1 试剂、药品与仪器 ...................................................................................................................6 2.1.1试剂、药品 ......................................................................................................................6 2.1.1仪器 ...................................................................................................................................6 2.2对比反应 ......................................................................................................................................7 2.3正式反应 .................