腹内高压对门静脉压、中心静脉压影响的实验研究.DOCVIP

临床医学论文-腹内高压对门静脉压、中心静脉压影响的实验研究 【摘要】? 目的 研究腹内压升高对大鼠中心静脉压和门静脉压的影响。方法 将20只成年雄性SD大鼠分别通过颈静脉插管、穿刺门静脉主干法来测定中心静脉压和门静脉压，运用氮气气腹法制作大鼠腹内高压动物模型。建立气腹后分别在0、5、10、15、20、25、30、35、40、45 mm Hg压力值下测得中心静脉压和门静脉压。结果 中心静脉压和腹内压之间的直线回归方程为Y＝2.824＋0.045X，相关系数r＝0.984(P＜0.01)；门静脉压和腹内压之间的直线回归方程为Y＝8.887＋0.939X，相关系数r＝0.998(P＜0.01)。结论 腹内压与中心静脉压和门静脉压有很好的相关性，可以根据腹内压监测中心静脉压和门静脉压的变化。 【关键词】? 腹内高压 中心静脉压 门静脉压 ???? Experiment study on intraabdominal hypertension affecting central venous pressure and portal venous pressure ??? WU Wei, ZHU Weiming, LI Ning. Research Institute of General Surgery, School of Medicine, Nanjing University/General Hospital of Nanjing Military Command,Nanjing 210002, China ??? 【Abstract】? Objective? To investigate the effect of intraabdominal hypertension on central venous pressure and portal venous pressure in rats. Methods? Twenty adult male SpragueDawley rats were used for measuring central venous pressure via jugular vein approach and measuring portal venous pressure via main portal venous puncture. Rat model of intraabdominal hypertension was established by injection of gaseous nitrogen into the peritoneal cavity. Then, the central venous pressure and the portal venous pressure were recorded at intraabdominal pressures of 0, 5, 10, 15, 20, 25, 30, 35, 40 and 45 mm Hg. Results? The regression equation of intraabdominal pressure and central venous pressure was Y=2.824+0.045X, with correlation coefficient of 0.984 (P＜0.01). The regression equation of intraabdominal pressure and portal venous pressure was Y＝8.887＋0.939X, with correlation coefficient of 0.998 (P＜0.01). ConclusionIntraabdominal pressure has close correlation with central venous pressure and portal venous pressure that can be detected by measuring intraabdominal pressure. ??? 【Key words】? Intraabdominal hypertension;? Central venous pressure;?? Portal venous pressure ??? 自Kron等［1］第一次提出了腹腔间室综合征(abdominal compartment syndrome,ACS)这一概念以来，临床医生逐渐认识到常规监测危重患者腹内压(Intraabdominal pressure,IAP)的重要性，相应地，腹内高压对循环和血流动力学的影