TP方案诱导化疗联合放疗治疗晚期鼻咽癌的近期疗效评价.pdfVIP

肿瘤药学 2014 年 4 月第 4 卷第 2 期　Anti-tumor Pharmacy, April 2014, Vol. 4, No. 2 - 131 - ●鼻咽癌专栏● TP 方案诱导化疗联合放疗治疗晚期鼻咽癌的 近期疗效评价 叶　旭 ，吴湘伟 ，刘　 雯，韩亚骞 ，陈艳平 （中南大学湘雅 医学院附属肿瘤 医院放疗科 ，湖南　长沙，4 10003 ） 摘要：目的　探讨 TP 方案诱导化疗联合放疗治疗晚期鼻咽癌的疗效。方法　以应用 TP 方案诱导化疗联合放 疗治疗晚期鼻咽癌疼痛的 55 例患者作为联合组，以单纯应用放疗的 53 例晚期鼻咽癌疼痛患者作为对照组，观察 两组患者鼻咽部病灶、颈部淋巴结转移及疼痛缓解情况。 结果　联合组患者鼻咽部病灶、颈部淋巴结转移改善情 况及疼痛缓解效果均显著优于对照组，差异有统计学意义（ 0.05）。结论　TP 方案诱导化疗联合放疗对局部晚 P 期鼻咽癌患者的近期疗效明显优于单纯放疗，可于临床进一步应用。 关键词：TP 方案；化疗；放射；晚期鼻咽癌 中图分类号：R739.6　文献标识码 ：A　文章编号：2095-1264（2014）02-0131-04 doi：10.3969/j.issn.2095-1264.2014.026 Short-term Effectiveness Evaluation of TP Induction Chemotherapy Followed by Radiotherapy for Local Advanced Nasopharyngeal Carcinoma YE Xu, WU Xiangwei, LI U wen, HAN Yaqian, CHEN Yanp ing (Dep artment of head and neck radiotherapy, the Aff iliated Cancer Hosp ital of Xiangya Medical School, Central South University, Changsha, Hunan, 410003, China) To explore the effectiveness of TP induction chemotherapy followed by radiotherapy for patients of Abstract: Objective local advanced nasopharyngeal carcinoma. Methods A total of 108 cases of local advanced nasopharyngeal carcinoma were in- cluded in this study. Fifty-five cases were treated with TP induction chemotherapy followed by radiotherapy as the union group, whereas other fifty-three cases were treated merely with radiotherapy as control group. Nasopharyngeal lesions, neck lymph node metastasis and pain relie