糖尿病患者甘油三酯-高密度脂蛋白胆固醇比值水平与胰岛素抵抗的关系.DOCVIP

临床医学论文-糖尿病患者甘油三酯/高密度脂蛋白胆固醇比值水平与胰岛素抵抗的关系 【摘要】? 目的 探讨血清甘油三酯/高密度脂蛋白胆固醇（TG/HDLC）比值水平与胰岛素抵抗的关系。方法 对146例2型糖尿病患者测定空腹胰岛素（FINS）、空腹血糖（FBG），TG，HDLC，低密度脂蛋白胆固醇（LDLC）水平，计算TG/HDLC比值，并按TG/HDLC和FBG水平分组，比较组间差异与胰岛素抵抗指数（HOMAIR）的关系。结果 糖尿病组TG/HDLC比值水平（2.531±3.741）显著高于正常对照组（0.898±0.487），差异有显著性（t＝4.279，P0.001）。TG/HDLC比值增高组HOMAIR（3.291±2.004）明显高于TG/HDLC比值正常组（2.403±1.789），差异有显著性（t＝2.796，P0.01）。血糖水平10 mmol/L 组HOMAIR（3.575±2.216）明显大于血糖水平≤10 mmol/L 组（2.384±1.584），差异有显著性（t＝3.760，P0.001）。结论 糖尿病患者TG/HDLC比值水平与胰岛素抵抗存在着密切的相关性。 【关键词】? 糖尿病；甘油三酯；高密度脂蛋白胆固醇；胰岛素抵抗 　　Abstract： Objective? To study the relation between triglyceride/high density lipoproteincholesterol (TG/HDLC) ratio level in serum and insulin resistance (IR) in diabetes.Methods? Parameters, such as fast insulin (FINS), fast blood glucose (FBG), TG, HDLC, low density lipoproteincholesterol (LDLC), were measured in 146 patients with diabetes Ⅱ. TG/HDLC ratio was calculated. The patients were divided into several groups according to serum TG/HDLC ratio and FBG level.Results? TG/HDLC ratio of diabetic group (2.531±3.741) was obviously higher than that of normal control group (0.898±0.487), and the difference between them was notably significant (t=4.279,P0.001). Homostasis model assessment (HOMA)IR (3.291±2.004) of the group whose TG/HDLC ratio was increased was obviously higher than that (2.403±1.789) of the group with normal TG/HDLC ratio, and the difference between them was notably significant (t=2.796,P0.01). HOMAIR (3.575±2.216) of the group with higher FBG level (＞10 mmol/L) was higher obviously than that (2.384±1.584) of the group with lower FBG level (≤10 mmol/L), and the difference between them was notably significant (t=3.760,P0.001).Conclusion? There is a compact correlation between TG/HDLC ratio and insulin resistance in diabetes. 　　Key? words： diabetes mellitus; triglyceride; highdensity lipoprotein cholesterol; insulin resistance ??? 糖尿病人群中常存在明显的脂代谢紊乱，其血脂异常多表现为甘油三酯（TG）水平异常升高及高密度脂蛋白胆固醇（HDLC）降低[1]。研究表明，血脂紊乱