高血压病、冠心病与血尿酸及血脂相关性探讨.DOCVIP

临床医学论文-高血压病、冠心病与血尿酸及血脂相关性探讨 ???????????????? 作者：冯美云 王丛 张昕 王增帅 张文祥 【关键词】? 冠心病 　　【摘要】? 目的? 探讨高血压病、冠心病与血尿酸（UA）及血脂的相关性。方法? 回顾性分析101例高血压病患者即高血压组（HBP）、101例冠心病患者即冠心病组（CHD）、166例高血压病合并冠心病患者即高冠心组和115例健康正常人（对照组）的UA及血脂检测值进行比较。结果? 3组UA、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、极低密度脂蛋白胆固醇（VLDL-C）、动脉硬化指数（LDL/HDL）均显著高于对照组（P＜0.01）；而高密度脂蛋白胆固醇（HDL-C）显著低于对照组（P＜0.01），高尿酸血症（HUA）在HBP组、CHD组、高冠心组中分别各占17.8%、9.1%、15.9%；相关分析显示,3组UA均与TG、TC、LDL-C、VLDL-C呈正相关，r=0.288、0.194、0.141、0.218，P＜0.01；与LDL/HDL亦呈正相关，r=0.194，P＜0.05；与HDL-C呈负相关（r=-0.291,P＜0.01）。3组间对比分析，HBP组及高冠心组UA显著高于CHD组（P＜0.05），HBP组与高冠心组两组间UA比较，差异无显著性（P＞0.05）；高冠心组TG和VLDL-C显著高于CHD组（P＜0.05），高冠心组与HBP组、HBP组与CHD组组间TG和VLDL-C比较差异无显著性（P＞0.05）。结论? 血尿酸升高是高血压病、冠心病的危险因素之一；UA升高与脂质代谢异常有关。??? 　　【关键词】? 高血压病；冠心病；血尿酸；血脂 　　Study on relationship between hypertension and coronary heart disease, level of serum urinary acid and blood lipidFENG Mei-yun,WANG Cong,ZHANG Xin,et al.First-aid Centre,The Second Affiliated Hospital of Medical Institute of Baotou,Baotou 014030,China 　　【Abstract】? Objective? To explore the correlation between the level of serum urinary acid and blood lipid with hypertension, coronary heart disease.Methods? We retrospectively analyzed the level of serum urinary acid and blood lipid with hypertension（n=101）,coronary heart disease（n=110）,hypertension incombinant coronary heart disease（n=166）,control group（n=115）,respectively.Results? The concentration of UA,TG,TC,LDL-C,VLDL-C,LDL/HDL of all patients group was higher than those of control group (P＜0.01) coronary heart disease, hypertension incombinant coronary heart disease was 17.8%,9.1%,15.9%,There were a positive correlation（r=0.288,0.194,0.141,0.218，P＜0.01) between UA and TG,TC,LDL-C,VLDL-C，and LDL/HDL（r=0.194，P＜0.05)；and a negative correlation（r=-0.291，P＜0.01) between UA and HDL-C.The concentration of HDL-C was lower than that of control group，P＜0.01,The percentage of hyperuricemia in hypertension of UA in HBP and hypertension incombinant coronary heart disease group was higher than CHD group,P