高血压病患者代文治疗前后血浆纤维蛋白原和血清钾浓度的变化.DOCVIP

临床医学论文-高血压病患者代文治疗前后血浆纤维蛋白原和血清钾浓度的变化 【关键词】? 高血压 　　摘要：目的:为观察高血压病患者代文(缬沙坦胶囊)治疗前后血浆纤维蛋白原［Fbg］和血清钾浓度的变化。方法:采用热浸淀比浊法和全自动生化分析仪分别测定23例正常人和53例高血压病患者代文治疗前和治疗12周后的血浆Fbg和血清钾浓度。结果:治疗前高血压病患者的血浆Fbg浓度明显高于正常人（4.32±0.46 g/L比3.5±0.34mmol/L，P0.01），而血清钾浓度明显低于正常人（3.5±0.34g/L比3.7±0.28 4mmol/L,P0.01）；代文治疗后血浆Fbg浓度降到3.24±0.35 g/L,P0.01),而血清钾浓度无明显变化(P0.05)。结论:提示高血压病患者的血浆Fbg水平升高而血清钾浓度偏低，代文在降低血压的同时降低血浆Fbg水平，但对血清钾浓度影响不大。 　　关键词：高血压病；纤维蛋白原；血清钾；代文 　　Changes of Plasma Fibrinogen and Serum K+ Concentration in Patients with Essential Hypertension Before and After Diovan Treatment 　　Abstract： Objective:To? investigate the changes of plasma fibrinogen and serum K+ and concentration in patients with essential hypertension before and after diovan (Caps Valsartan)treatment.Method:Plasma fibrinogen and serum K+ and concentration were measured with therncoprepilatic turbidimetry automtic biochemical analysis apparatus in 23 norotensive controls and 53 patients with essential hypertension before and after ks of treatment with Diovan. Result: The baseline concentrations of plasma fibrinogen were significantly higher in hypertensive patients than?in?nomotonsive?controls (4.32?.46g/L vs3.5?.34g/L,P0.01).while the levels of serum K+?were lower in hypertensive patiens than in normotensivecontrols?(3.50?.34mmol/Lvs.3.7?.28mmol/L,P0.01).After 12 weeks treatment of Diovan ,plasma fibrinogen concentrations had fallen to 3.24?.35g/L(P0.01).while serum K+ concentrations didn抰 change.Conclusion: Plasma fibrinogen levels are higher while serum K+ concentrations are lower in patients with hypertension. Diovan can decrease blood pressure as well as plasma fibrinogen concentrations ,but doesn抰 change the levels of serum K+. 　　Key words：Essential? hypertension；Fibrinogen；K+；Diovan??????????????????????????????????????? 　　高血压的发病率日益增多，其并发症已成为危害全球中老年人身体健康的严重疾病，虽然其发病因素尚未完全阐明，但有关资料表明高血压病患者的血浆Fbg浓度明显升高［1，2］,而血清钾浓度偏低［3，4］,并认为是高血压的重要致病因子。本文观察高血压病患者的血浆Fbg和血清钾浓度的变化及代文治疗对它们的影响。现将结果报告如下。 　　1 对象与方法 　　1.1 对象：①高血压患者53例，男34例，女19