贝美前列素的临床观察.DOCVIP

临床医学论文-贝美前列素的临床观察 ?【摘要】?? 目的?? 观察贝美前列素点眼降低眼压的作用与副作用。方法?? 用贝美前列素对发育性青光眼、原发性开角型青光眼与高眼压症共62眼点眼与国产噻吗心安20眼点眼1个月后进行比较，贝美前列素点眼所致的药物性结膜炎进行观察6个月。结果?? 贝美前列素每晚点眼1次，其降低眼压作用优于国产噻吗心安每日点眼3次（P＜0.05），贝美前列素可达56%以上。结论?? 贝美前列素是一种有效的抗青光眼制剂，药物性结膜炎是其主要的副作用。 ??? 【关键词】?? 贝美前列素；青光眼；高眼压症 ???? Investigation of the clinical effect of bimatoprost ??????? 【Abstract】?? Objective?? To investigate the decreasing of the intraocular pressure and the side effect of topical administration of Lumigan （bimatoprost）.Methods?? Totally 82 eyes of developmental glaucoma，primary open-angle glaucoma and ocular hypertension were observed.In which 62 eyes were topically administered by Lumigan for one months，the other 20 eyes were treated by timolol.The conjunctivitis induced by Lumigan was observed for 6 months.Results?? Administration with one time of Lumigan droping each night could make a farther decrease of intraocular pressure than that with timolol droping three times a day（P＜0.05）.The longer the treatment with Lumigan，the more likely the conjunctivitis occurred，and the more serious the conjunctivitis manifested.The rate of induced conjunctivitis was 56% after 6 months of treatment with Lumigan.Conclusion?? Lumigan was an effective anti-glaucoma agent.Conjunctivitis was its chief side effect. ??? 【Key words】?? bimatoprost；glaucoma；ocular hypertension ??? 贝美前列素（Lumigan， Bimatoprost）点眼剂是第二代前列素抗青光眼药，在国外已成为一线抗青光眼制剂［1］，国内的临床观察较少，特别是较长期的临床观察更少，讨论其副作用的资料更不多见。故将笔者的临床资料总结分析如下。 ??? 1?? 资料与方法 ??? 1.1?? 一般资料?? 自2002年1月～2005年6月观察用贝美前列素点眼的患者共32例（62眼），其中男20例，女12例，年龄12～78岁，平均45岁。其中发育性青光眼16例，高眼压症10例。全部患者均为郑州市二院眼科和郑大一附院眼科门诊患者，点用该药前停用原抗青光眼治疗1周，未有行抗青光眼手术及激光治疗者，排除患者重要眼病，如葡萄膜炎及白内障等。所用贝美前列素由在美开业医师及患者家属协助购买。 ??? 1.2?? 治疗方法?? 受观察者测眼压后用贝美前列素每晚点眼1次，点眼时间为每晚7～10点，第二天上午来院测眼压，这样每晚持续点眼，以后每周来院检查1次，检查视力、眼压、裂隙灯及眼底等，同时与20眼单独用国产0.25%噻吗心安每日3次点眼的患者1个月后进行了降低眼压结果的比较。 ??? 2?? 结果 ??? 2.1?? 两组眼压下降结果比较?? 贝美前列素组的眼压下降值为（7.83±4.02）mmHg，噻吗心安组为（2.69±2.07）mmHg，两组比较差异有显著性（P＜0.05）。 ??? 2.2?? 副作用观察?? 在点用贝美前列素过程中最长观察了6个月，除定期检查了视力、眼压、视野及眼底外，外眼反应性炎症及药源性结膜炎是最常见的