_环糊精衍生物超分子体系识别机理及其在手性分离中应用.pdf

20 10 4 Vol. 28 No. 4 April 2010 Ch inese J ourna l of Chrom atog rap hy 413~ 421 专论与综述 DOI: 10. 3724 /SP. J. 1123. 2010. 00413 * 李 霞, 周智明 , 孟子晖 (, 10008 1) : CD, ( CD) , pH , X, CD : ; ; ; : O65 8 : A : 100087 13(2010 Recognition mechanism of supramolecular systems of cyclodextrin derivatives and applications in chiral separation * LI X ia, ZHOU Zhmi i g , MENG Zihui (Sch oo l o f Ch em ica l En g in eer in g E nv ironm en , Beij in g In s i u e o f T echn o lo gy , Beij in g 100081, Ch in a ) Abstract: cyclodextri (CD) has the cavity i which the exterior is relatively hydrophilic a d the i terior is relatively lipophilic a dmultihydroxylgroups o it. So CD ca bemodified by differe t substitue t groups a d form supramolecular systems w ith guests, a d are applied to ma y fields. Recog itio mecha ism ofCD derivatives supramolecular system s is reviewed herei . Effects of structures of host a d guest, solve t, buffer pH a d li kage styles of statio ary phase a d study methods of ultrav ioletvisible, fluoresce ce spectroscopy, circular dichro ism spectrum, uclear m ag etic reso a ce, thermody am ics, Xray a d molecular dy am ics smi ulatio o mecha ism are expou ded. The applicatio s i chiral separatio are also i tro duced. Thism ight lay a fou datio for studyi g the ge eral law of recog itio mecha ism. Key words: cyclodextri derivatives; supramolecular system; recog itio mecha ism; chiral separatio OH)