一个基于熵的精细定位数量性状位点的指数.pdfVIP

Journal of Genetics and Genomics (Formerly Acta Genetica Sinica) April 2007, 34(4): 373-380 Research Article An Entropy-based Index for Fine-scale Mapping of QTL 1,3 2,3,① 1 2 Yang Xiang , Yumei Li , Zaiming Liu , Zhenqiu Sun 1. College of Mathematics, Central South University, Changsha 410081, China; 2. School of Public Health, Central South University, Changsha 410078, China; 3. Mathematics Department of Huaihua College, Huaihua 418000, China Abstract: By comparing the entropy and conditional entropy in a marker, an entropy-based index for fine-scale link- age-disequilibrium gene mapping is presented using high-density marker maps in extreme samples for quantitative trait. The en- tropy-based index is the function of LD between the marker and the trait locus and does not depend on marker allele frequencies across the loci. It is parallel to Hardy-Weinberg disequilibrium (HWD) measure for QTL fine mapping, but its power of fine map- ping QTL is higher than that of HWD measure. Through simulations, the fine mapping performance of this entropy-based index is investigated extensively under various genetic parameters. The results show that the indices presented here are both robust and powerful. Keywords: entropy; entropy-based Index; QTL; fine mapping When designing a fine-scale mapping study, it is gosities in a marker. Although HWD measures are assumed that a region linked to a putative dis- robust and powerful for their excellent properties of ease-susceptibility locus (DSL) or quantitative trait being independent of marker allele frequencies, the locus (QTL) has a