出生时母血和脐血重金属水平与2 岁幼儿神经心理发育的关系研究.docVIP

作基地儿童保健科）[摘要] 目的 探讨重庆市铜梁地区燃煤电厂关闭前后环境污染物（重金属铅、镉、汞）对儿童早期神经心理发育的影响。方法 本研究采用前瞻性队列研究方法，纳入309对健康母子，分别检测母血和脐血血清铅、镉、汞水平，并测试幼儿2岁时的神经心理发育水平。结果 该地区燃煤电厂关闭前后出生婴儿母血与脐血重金属（铅、镉、汞）水平均无明显统计学差异（P0.05）；燃煤电厂关闭前后出生婴儿在其2岁时Gesell量表所测运动、适应行为、语言、个人-社会发育商和平均发育商无明显统计学差异（P0.05）。脐血汞水平与2岁幼儿语言、个人-社会及平均发育商存在负相关（β=-0.136, β=-0.241, β=-0.182, P0.05）；脐血铅高水平组（34.3μg/L）各能区发育商均低于脐血铅低水平组（≤34.3μg/L），组间适应行为和个人-社会发育商有统计学差异（P0.05）。结论 环境重金属污染可影响儿童神经心理发育。 [关键词]重金属；脐血；神经心理发育R195 [文献标志码] A Impact of heavy metals at birth on Neuropsychological development of children assessed at two years age Fan Zhen1, Wei Xiaoping1, Zhang Xuan1, 2, Liu Yongfang1, Jiang Hongpeng1, Chen Qian1, Jiang Wei1, Gong Ming1, Qu Ping1, Chen Jie1, Liu Youxue1, Chen Li1, 2, Li Tingyu1, 2 (Children’s Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders1; Child Health Care Department2, Children’s Hospital of Chongqing Medical University, Chongqing, 400014, China) [Abstract] Objective To investigate the correlation of the heavy metals status (lead, cadmium and mercury) during pregnancy and the neuropsychological development of early childhood before and after the shutdown of the coal-fired power station. Method A total of 309 paired maternal-neonatal subjects were recruited into the present study. The serum concentrations of lead, cadmium and mercury in maternal blood and cord blood after delivery were determined. The neuropsychological development was evaluated at two-years-old. Result After adjusting for potential confounders, there were no significant differences statistically in comparison between maternal and cord blood levels of heavy metals (lead, cadmium and mercury) of infants born before and after the shutdown of the coal-fired power station (P0.05), and the comparison of all the development quotients (motor, adaptation,