川芎素对肾性高血压并慢性肾功能不全患者血浆ET-1和NO的影响.pdfVIP

2002, 27( 5) BULL HUNAN MED UNIV 445 ET1NO 杨敬华, 周巧玲, 成小苗, 邓声莉, 吴彩玲 ( 中南大学湘雅医院肾内科, 长沙 410008) [ ] 目的:观察轻中度肾性高血压合并慢性肾功能 全患者血浆ET1 和NO 水平变化及川芎素对其干预 作用方法: 轻中度肾性高血压并慢性肾功能 全患者60例分为A 与B 组, A 组静滴川芎素300mg, 每日1 次, 加对 症治疗; B 组采用对症治疗, 疗程均为2 周选择20例健康体检者作为对照组( C 组) 用放射免疫方法测定血浆ET 1 浓度和生化比浊法测定血浆NO 水平结果:A, B 组血浆ET1 浓度明显高于C 组( P 0.01) , 而血浆NO 浓度明显 低于C 组( P 0.01) A 与 B 两组治疗前后血浆ET1, NO, BUN, Scr, 尿蛋白定量比较差异有显著性( P 0. 01) ET1与血压成正相关(= 0. 52 P 0.01) , 而NO 与血压成负相关(= - 0. 345, P 0. 01) 结论: 轻中度肾性高血 压并慢性肾功能 全患者血浆ET1 浓度高于正常人, 血浆NO 浓度低于正常人川芎素具有调节患者血浆ET1 与 NO 浓度, 减少尿蛋白排泄, 改善肾功能作用 [ ] 川芎素; 内皮素; 一氧化氮 + [ ] R544. 1 4 [ ] A [ ] 2002) Effects of sodium ferulate on plasma levels of endothelin1 and nitric oxide in patients with renal hypertension and chronic renal insufficiency YANG Jinghua, ZHOU Qiaoling, CHENG Xiaomiao, et al . ( Dep artment of Nephrol ogy , X iangya H osp ital , Central South University , Changsha 410008, China) Abstract: Objective To observe the changes of plasma Endothelin1 ( ET1) and nitric oxide (NO) , and the treatment effect of sodium ferulate on patients with renal hypertension and chronic renal insufficiency. Methods Group I: sixty patients with renal hypertension and chronic renal insufficiency were divided into two groups randomly: A and B. The patients in Group A were treated with sodium ferulate and the routine therapy while those in Group B were treated only with the routine therapy. The serum concentration of ET1 and NOwere measured. Re