通过QCM-D研究蛋白质与有机硅油之间相互作用.pdfVIP

通过QCM-D研究蛋白质与有机硅油之间相互作用.pdf

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Pharm Res DOI 10.1007/s11095-012-0696-6 RESEARCH PAPER Mechanistic Understanding of Protein-Silicone Oil Interactions Jinjiang Li Swathi Pinnamaneni Yong Quan Archana Jaiswal Fredrik I. Andersson Xiaochun Zhang Received: 18 August 2011 /Accepted: 27 January 2012 # Springer Science+Business Media, LLC 2012 ABSTRACT KEY WORDS adsorption . aggregation . protein . silicone-oil . Purpose To investigate interactions between protein and silicone syringes oil so that we can provide some mechanistic understanding of protein aggregation in silicone oil lubricated syringes and its pre- vention by formulation additives such as Polysorbate 80 and INTRODUCTION Poloxamer 188. Methods Interfacial tension values of silicone oil/water inter- As proteins become important therapeutic agents in treating face of abatacept solutions with and without formulation diseases, the delivery of these drugs faces ever increasing additives were obtained under equilibrium conditions using challenges. Prefilled glass syringes (PFS) have become the Attension Theta optical tensiometer. Their adsorption and container of choice for storing and administering therapeu- desorption profiles were measured using Quartz Crystal tic protein products to patients ( 1). Proteins tend to interact Microbalancing with Dissipation monitoring (QCM-D). The with surfaces of such delivery device due to their amphiphil- degree of aggregation of abatacept was assessed based on ic nature, leading to aggregate formation. Particularly, their size exclusion measurement. interaction with a syringe lubricant (silicone oil) has been Results Adsorption of abatacept at the oi

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