表皮生长因子甘草锌复合膜治疗口腔溃疡的实验研究.pdfVIP

608 栽蚤葬灶躁蚤灶 酝藻凿 允熏 Jul 圆园10熏 灾燥造 38 晕燥 7 表皮生长因 甘草锌复合膜治疗口腔溃疡的实验研究* 凤昆 孙 磊 摘要 目的：探讨表皮生长因 甘草锌复合膜对口腔溃疡动物模型的疗效。方法：将24 只家兔随机分为治疗组、 对照组和空白组，各8 只。以冰醋酸润湿脱脂棉，在家兔右侧靠口角黏膜处烧灼1 min ，生理盐水冲洗5 min ，24 h 形成 溃疡。溃疡形成后每日8 ：00、12：00、16 ：00 对家兔进行麻醉，空白组不做治疗，治疗组和对照组分别使用复合膜和本 院制剂溃疡糊剂治疗2 h ，疗程为 5 d，每日测量家兔溃疡面最大直径，进行组间对 观察。结果：（1）治疗至第3 天时， 治疗组疗效优于对照组及空白组（P 0.05 ），对照组与空白组差异无统计学意义（P 跃 0.05 ）；治疗第 5 天时，治疗组及 对照组疗效差异无统计学意义（P 跃 0.05 ），但均优于空白组（P 0.05 ）。（2）在外观治愈的家兔 ，对照组家兔组织上皮 已修复，但 正常组织薄，固有层纤维 正常组织疏松；治疗组家兔上皮表面不全角化，与正常组织形态基本一致。结 论：表皮生长因 甘草锌复合膜治疗口腔溃疡疗效确切。 关键词 表皮生长因 甘草 锌 膜剂 口腔溃疡 口腔黏膜 上皮 兔 模型, 动物 An Experimental Study of Oral Ulcer by Compound Epidermal Growth Factor and Glycyrrhizic Zinc Pellicles in Rabbits YANG Fengkun袁SUN Lei Tianj in Stomatological Hospital, Tianj in 300041, China Abstract Obj ective: To investigate the efficacy of compound epidermal growth factor and glycyrrhizic zinc pellicles in oral ulcer animal model. Methods: Twenty -four rabbits were randomly divided into treatment group, control group and blank control group(n = 8 for each group). The ulcer rabbit model was made by using wet acetic acid cotton to burn at the right mouth mucosa for 1 min, and was washed by normal saline for 5 min. The oral ulcers were formed after 24 h. The rabbits were anes鄄 thetized at 8 院00, 12 院00, 16 院00 every day. The rabbits in treatment group were treated with the compound pellicles, the rabbits in control group were treated with ulcer paste and the rabbits in blank control group with no treatment. The treatment was 2 h every day for 5 days. The daily measurements of maximum diameter of ulcers were taken in rabbits, and compari