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of onNewbron
Effect
NeuroprotectiVeBax—InhibitingPeptide
RatswithNeonatal Ischemic
Hypoxic Damage
Abstract
theeffectsof on neuronal
objective:Toinvestigate Bax—inhibitorypeptideimproving
innewbornratswith brain
damage(HIBD).
apoptosis hypoxia—ischemic
Method:Twohundred newbornwisterratswere dividedintothree
7-day—old randomly
modelwas
groups:Shamoperationgroup,controlgroup,experimentgroup.HIE
established oftheleftcarotid with2h in
byligation arteryalong 8%oxygenexposure
sham was
neonatalratsofthecontroland not
experimentgroups.Theoperationgroup
an
to received
subjectedhypoxia—ischemia.111eexperimentgroup
withdoseof in
ofbax—inhibitory oh,6h,12h,
injection peptide 5ug(5u1)respectively
at
24h,48hand3dafter theothertwo receivednormalsalinethe
HIBD,while groups
7d
sametime.Eachofmicewere the12h,24h,48h,3dandafter
group sacrificed,on
miceineach after with andbrains
HIBD,taketwo sub—groupperfusionformaldehyde
wereremovedfor detectionHE takesixmi
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