多西他赛自乳化固体分散体的制备及体外特性研究_陈鹰.pdfVIP

广东药学院学报 J ournal of Guangdong Pharm aceutical Co lleg e Jun. 2010, 26( 3) 陈鹰, 张红, 史琼枝, 刘宏 ( , 430070) : ( DTX-SESD ) , PEG 6000, , X- DTX-SESD 33. 8 12. 5( 2 h) ; ; ; ; : ; ; ; : R 94 : A do:i 10. 3969 / . issn. 1006- 8783. 20 10. 03. 001 : 1006- 8783( 2010) 03- 0221- 05 Preparation and characteristics in vitro of docetaxel in self-emulsifying solid dispersion CHEN Y ing, ZHANG H ong, SH I Q iong-zh i, LIU H ong (Dep t. of P harm aceu tica,l W uhan Genera lH osp ital of Guang zhou Comm and, Wuhan, H ubei 430070, China) Abstract: Objective T o study on the preparation of docetax el self-em uls ify ing solid d ispers ion ( DTX- SESD) and its characteristics in vitro. MethodsSelf-em u ls ify ing solid dispers ion of docetaxelw as p repared w ith PEG6000 and other self-em u lsify ing excipients. The solub ility, stab ility and d issolution exper mi ents w ere carried out w ith d ifferent sel-f em u lsify ing ex cip ien ts, preparation m ethods and m ed ias. D ifferen tial therm al analys is and powderX-ray d iffraction w ere em p loy ed to identify the drug status in carr iers. Results The so lub ility and d issolution of DTX-SE SD w ere respectively 33. 8 and 12. 5 ( 2 h ) folds as tho se of the drug crude pow der. S ign ificant in fluence of d ifferent self-emu lsify ing excip ien ts w as ob served on the d issolu tion of DTX-SE SD, and the d isso lution of DTX-SESD prepared by the solvent m ethod and solv en-t m elting m ethod w ere better than that w ith the m elting m ethod. There w ere no apparen t d ifferences am ong the d issolution m ed ias. Drug s in DTX-SESD w erem ain ly m olecu les. Conclusion It can greatly mi prov e the solub ility and d issolution of docetax elw ith self-em u