Construction of ion selective membrane electrodes for the potentiometric determination of enalapril maleate in its pure form and pharmaceutical preparations.docVIP

Construction of ion selective membrane electrodes for the potentiometric determination of enalapril maleate in its pure form and pharmaceutical preparations. *Ali Ibraheem Khaleel and **Fadam Muteb Abdoon Pharmacy College / University of Tikrit , Sallah AL-Den , Iraq. *Email: ali_aljuboori2002@ ** Email: fadamabdon@ (NJC) (Recevied on 15/4 /2012 ) (Accepted for publication 1/7/2012) Abstract Two novel enalapril maleate (ENM) ion selective electrodes were constructed and used for the determination of ENM in its pure form and pharmaceutical formulations. The electrodes were based on the use of the ion association complexes of either phosphotungstic acid (PTA) or phosphomolybdic acid (PMA) as anions with Enalapril cation in a PVC matrix plasticizers with di-butyl phthalate (DBP). The results of these electrodes showed stability (life time 33 and 51 days), near Nernstian response (slope 57.2 and 52.2 mV/decade ), low detection limit (1.3×10-7 and 4.2×10-7 M ) for DBP-ENM-PTA and DBP-ENM-PMA electrodes respectively. For both electrodes the best concentration for internal filling solution was 1×10-3 M ENM and the linear range was 1×10-5- 1×10-1 M. The electrodes were found to be usable within the pH range 2.2 – 3.8 and 2.5 – 3.0 for the above mentioned electrodes. This study also included the measurements of selectivity of these electrodes in the presence of common cations, anions and some drug excipients. The found to be less than 1. The electrodes were successfully applied for determination of ENM in pure form and in tablet pharmaceutical preparation with recovery of not less than 98 %. Keywords: Enalapril, potentiometric determination, ion selective membrane electrodes. ??????? ?? ?? ??? ????? ????? ????? ????????? ?????? ???????????? ?? ???? ????? ??? ????????? ?????????? ????????? ??? ???? ??????? ??????? ??????? ??? ??????? ??? ???? ????????????? (PTA) ?? ???? ?????????????? (PMA) ????????? ???????????? ???????? ????? ?????? ???????? (DBP) ????? ??