安徽地区109株金黄色葡萄球菌的临床分布及耐药性分析.pdfVIP

第 33 卷第 10 期 安 徽 医 学 2012 年 10 月 Anhui Medical Journal 1269 ·临床医学· 安徽地区 109 株金黄色葡萄球菌的临床分布及耐药性分析 汪 滢 李家斌 ［摘 要］ 目的 探讨金黄色葡萄球菌感染的临床分布及耐药特点，为临床诊断和治疗提供依据。 方法 109 株金黄色葡萄球菌药 敏试验采用琼脂稀释法 ， 结果依据 CLSI 2010 年推荐的标准进行判读。 结果 金黄色葡萄球菌在呼吸道痰标本中检出率最高，达 31.2% ；主要分布于重症监护病房、骨科、儿科等；药敏结果显示，金黄色葡萄球菌对青霉素、氨苄西林、克林霉素、阿奇霉素和红霉素高度 耐药，耐药率均高于 90% ；对头孢他啶耐药率达 50% ，对其他三四代头孢菌素耐药率在 25%左右；对喹诺酮类抗菌药物耐药率较高，达 40% ；对氨基糖苷类中的阿米卡星敏感性高，敏感率达 85.2% ；利福平具有较高的敏感性，达 84.0% ；尚未发现对万古霉素、替考拉宁及利奈 唑胺耐药的菌株。 结论 安徽地区金黄色葡萄球菌对多种抗菌药物耐药，临床应加强对金黄色葡萄球菌耐药性的监控并防止耐药菌株 的传播流行。 ［关键词］ 金黄色葡萄球菌；药物敏感试验；细菌耐药监测 doi ：10.3969/j.issn.1000-0399.2012.10.001 Distribution and resistance surveillance of 109 clinical strains of staphylococcus aureus in Anhui province Wang Ying ， Li Jiabin Department of Nutrition ， the No. 306 Hospital of the People s Liberation Army ， Beij ing 100 10 1， China [Abstract] Objective To analyze the clinical distribution and antimicrobial resistance of Staphylococcus aureus （S. aureus ）in order to provide the scientific evidence for clinical diagnosis and treatment. Methods The antimicrobial susceptibility test to 109 strains of S. aureus was performed by agar dilution method. The results were judged according to the criteria recommended by Clinical and Laboratory Standards In－ stitute （CLSI ）2010. Results The majority of S. aureus were isolated from the specimen of sputum ， accounting for 31.2%. The bacteria was frequently distributed in Intensive Care Unit ， followed by Department of Orthopedics ， Department of Pediatrics. The results of antimicrobial sus－ ceptibility test showed that S. aureus was highly resistant to penicillin ， ampicillin ， clindamycin ， azithromycin and erythromycin