艾司西酞普兰治疗抑郁症患者的早期疗效及其与血药浓度的关系.pdfVIP

·238 · J Clin Psyc iatry，2014，Vol24，No.4 ·论著· 艾司西酞普兰治疗抑郁症患者的早期疗效 及其与血药浓度的关系 王丹逢，朱海兵，伍远菲，蓝晓嫦 摘要： 目的：探讨艾司西酞普兰治疗抑郁症患者的早期疗效及其与血药浓度的关系。 方法：对 47例抑郁症患者应用艾司西酞普兰系统治疗，于治疗前及第1、2周进行汉密顿抑郁量表 17项（HAND） 评估，同时采用高效液相色谱-质谱法（HPLC-MS）测定血药浓度。 结果：治疗1周有效率23.4±，无患 者治愈；血药浓度在有效者［13.43±4.78）ng/ ml］与无效者［（11.28±10.30）ng/ ml］间差异无统计学意 义。治疗2周治疗有效率59.6±，治愈率为25.5±；血药浓度有效者［（18.97 ±13.77）ng/ ml］与治愈 者［（19.65±11.42）ng/ ml］差异无统计学意义，但均显著高于无效者［（6.52 ±3.36）ng/ ml］（P 均﹤ 0.01）。有效者治疗1、2周时焦虑/ 躯体化因子分较无效者显著改善（P ﹤0.05 或P ﹤0.01）。 结论 艾司西酞普兰治疗抑郁发作（含伴焦虑）早期疗效良好；监测其血药浓度具有临床意义。 关键词： 艾司西酞普兰； 抑郁症； 血药浓度 中图分类号： R749.4 文献标识码： A 文章编号： 1005-3220（2014）04-0238-03 Early efficacy and its correlation with Plasma concentration of escitaloPram in Patients with dePression WANG Dan-feng，ZHU Hai-bing，WU Yuan-fei，LAN Xiao-chang. Guangzhou Brain Hospital，Guanzhou 510370，China Abstract Objective To explore t e early efficacy and its correlation wit plasma concentration of es- citalopram in patients wit depression. Method Forty-seven depressive patients receoived escitalopram sys- tem treatment.T eywereassessedby Hamiltonrating scalefor depression-17 items（HAMD）beforetreatment， one and two weeks after treatment. Meanw ile，t eir plasma concentration of escitalopramwas detected by ig performance liquid c romatograp y-massspectrometry（HPLC-MS）. Results Att eendoft efirstweek，t e effective rate was 23.4± and no one was of cure.T e plasma concentrations between t e effective patient ［（13.43±4.78）ng/ ml］and invalid patients［（11.28±10.30）ng/ ml］was no significantly difference. At t e end of t e secondweek，t eeffectiveratewas59.6± andcureratewas25.5±.T eplasmaconcentrationsbe- tween t e effective patient［（18.97±13.77）ng/ ml］and t e recovered patients［（19.65 ±11.42）ng/ ml］was no significantly different；but all of t ose were significantly i