我院抗菌药物临床应用与细菌耐药分析.pdfVIP

用药分析 我院抗菌药物临床应用与细菌耐药分析 1 1 1 1 2 （1 新疆自治区人民医院，乌鲁木齐，83000 1；2 新疆和田地区人民医院，和田， 李红健 ，曹丽蒙 ，韩燕 ，蒋玉凤 ，阿孜古丽 848000 ） 摘要 目的：分析我院抗菌药物应用及临床分离菌对常用抗菌药物的耐药性情况，为临床合理用药提供参考。方法：采用 K-B 法进行药敏分析，并按CLSI 标准判断病原菌耐药性，对用药频度（DDDs ）以及检出细菌耐药的变化情况进行分析。结 果：我院抗菌药物DDDs 变化较大，注射用左氧氟沙星使用明显上升。2007、2008 年一季度医院感染病原菌仍以革兰阴性菌 为主，分别占7 1.43% 和68.26% 。葡萄球菌属中未发现对万古霉素、替考拉宁和利奈唑胺耐药株。各种肠杆菌科细菌对亚胺 培南和美罗培南均高度敏感，耐药率低于13% 。大肠埃希菌对喹诺酮类耐药率较高（ 60% ）。两年度细菌耐药情况虽有波 动，但变化不大，细菌耐药性仍呈增长趋势。结论：医院应采取有效措施，加强病原菌的耐药监控，合理使用抗菌药物。 关键词 抗菌药物；用药频度；合理用药；细菌耐药 中图分类号：R978.1; R969.3 文献标识码：A 文章编号：1672 – 8157(2009)05 – 0291 – 04 Antibacterials Usage and Analysis of Bacterial Resistance in Our Hospital 1 1 1 1 2 LI Hong-j ian , CAO Li-meng , HAN Yan , JIANG Yu-feng , A Zi-guli (Xinjiang Peoples Hospital, Urumqi, 830001; 2 Hetian People’s Hospital, Hetian, 848000) ABSTRACT Objective: To investigate the usage of antibacterials and the drug resistance of the bacterials isolated from clinical samples for rational use of antibacterials in clinic.Methods: K-B paper disk diffusion method was employed in drug sensitivity test, and the drug resistance of pathogenic bacteria was identified by the CLSI standard.DDDs of antibacterials and changes of bacterial resistance were investigated.Results: DDDs of antibacterials varied significantly, especially levofloxacin for inj ection. Gram negative bacteria in our hospital was the main pathogenic bacteria during the first quarter of 2007 and 2008, accounting for 71 43% and 68 26% respectively No isolated staphylococcal resistant to vancomycin, teicoplanin or linezolid was found Isolates . . . . o