Determination of optimal source-detector separation in measuring chromophores in layered tissue with diffuse reflectance.pdfVIP

维普资讯 November10，2005／Vo1．3，No．11／CHINESEOPTICSLETTERS 659 D’’～eterm i●nati●on of^opti●m al‘SourCe—de‘tectorseparatio‘n l●n m eaSUrl●ng Cn1rom oDn1ores l●n layere=‘It-l●SSUe with diffusereflectance YunhanLuo(罗云瀚)，HouxinCui(崔厚欣)，XiaoyuGu (谷筱玉)， RongLiu (刘 蓉)，andKexinXu (徐可欣) StateKeyLaboratory ofPrecisionMeasuringTechnology andInstruments， CollegeofPrecisionInstrumentandOpto—ElectronicsEngineering,TianjinUniversity,Tianjin300072 ReceivedMarch 9，2005 Basedonanalysisoftherelationbetweenmeanpenetrationdepthandsource—detectorsepraationinathree— layermodelwiththemethodofMonte—Cr!alosimulation．anoptimalsource—detectorsepra ationisderived from themean penetration depth referring to monitoring thechangeofchromophoresconcentration of thesandwiched layer．Inordertoverifvthesepraation．weperform Monte—Cralosimulationswithvraied absorption coefficient ofthe sandwiched layer． AlJthesediffuse reflectancesrae used t0 constructa calibrationmodelwiththemethodofpratialleastsquraefPLS1．Highcorrelationcoefficientsandlow root meansquraeerrorofprediction (RMSEP1attheoptimalsepraationhaveconfirmedcorrectnessofthe selection．Thistechniqueisexpectedtoshow lightonnoninvasivediagnosisofnera．infrraed spectroscopy． ocIscodes：170．O170．300．0300． In theapplicationsofnearinfrared spectroscopy used depthofd． for diagnostic goals，it isessentialto study penetra- W henphotonsmigrateinturbidmedium ．theirweight tion depthofdiffused photonsr-eemittingfrom irradi— willbelostaccordi