他克莫司软膏联合窄谱中波紫外线治疗白癜风疗效观察.pdf

44 I 舞 l 鐾凄，嚣 他克莫司软膏联合窄谱中波紫外线治疗 白癜风疗效观察 陈 自学，倪文琼，魏芳，张雪，高歌 [摘 要] 目的 探讨他克莫司软膏联合窄谱中波紫外线 (NB—UVB)治疗 白癜风的疗效和安全性。方法 82例 白癜风患者随机分成两组。治疗组43例 ，外用他克莫司软膏，2次／d，NB—UVB光疗，每周2次，疗程 16 周。对照组39例单纯予NB—uVB光疗，用法同上。结果 治疗组有效率为72．1％，对照组为48．7％， 两组有效率差异有显著性(P0．05)。治疗组皮损位于面颈部、躯干和四肢者疗效优于对照组 (P 0．05)，两组肢端皮损疗效差异无显著性(P0．05)。患者均未出现严重不 良反应。结论 他克莫司 软膏联合 NB，UVB治疗位于面颈部、躯干和四肢的白癜风疗效好 ，不 良反应少。 [关键词] 他克莫司；窄谱中波紫外线；白癜风 [中图分类号] R758．4；R730．55 [文献标识码] B [文章编号] 1001—7089(2olo)o5—0440—02 Efficacy Observation ofTacrolimusOintmentCombined with Narrow-band UltravioletB Phototherapy in the TreatmentofVitiligo CHEN Zi—xue，NIWen—qiong，WEIFang，ZHANGXue，GAO Ge (DepartmentofDermatologyandVenereology，theCentralHo@italD厂Zhengzhou，Zhengzhou450007，China) [Abstract] Objective Toinvestigatetheefficacyandsafetyoftacrolimusointmentcombinedwithnarrow—banduhraviolet B(NB—UVB)phototherapyinthetreatmentofvitiligo．Methods Eighty—twopatientswithvitiligoweredivided intotwogroupsrandomly．Fony—threepatientsoftreatmentrgoupweretreatedtwicedailywithtacrolimusoint— mentcomb inedwithNB—UVBphototherapytwiceweeklyfor16weeks．Similarly，thirty—ninepatientsofcontrol rgoupwereonlytreatedwithNB—UVBphototherapytwiceweeklyofr16weeks．Results Thetotaleffective rateoftreatmentgroupwas72．10％ andthatofcontrolgroupwas48．70％ ．Therewassignificantdifference betweentwogroups(P0．05)．Theeffectoftreatmentgroupissuperiortothatofcontrolgrouptothevitili— gouslesionslocatedonfacenecktrunkandextremities(P0．05)．However，therewasnotstatisticalsignifi— cancebetweentworgoupsintheeffectiverateofacra1lesions(P0．05)．Noseriousadverseeventswerere— cordedinbothgroups．Conclusion Thecomb inationoftacrolimusointmentwithNB—UVBphototherapycan representaneffectiveandwell—toleratedapproachtovitiligolocatedonfaceneckturnkandex