咪喹莫特乳膏联合卡介菌多糖核酸治疗扁平疣疗效观察.pdf

44 IC．辛H阊Ili边!I)碱tmi性llV病B学I1EIR汆B奄OLIMay2．Olo期,Vo№5 咪喹莫特乳膏联合卡介菌多糖核酸治疗 扁平疣疗效观察 黄明欢 ，秦晓峰 ，黄懿 ，姚玮 [摘 要] 目的 探讨咪喹莫特乳膏联合卡介茵多糖核酸治疗扁平疣的临床疗效和安全性。方法 78例患者随 机分为两组，试验组40例外用5％咪喹莫特乳膏，每晚1次，对照组38例外用0．1％维A酸乳膏，每晚 1次，两组同时肌 肉注射卡介茵多糖核酸2mL，每周 3次，8周为一疗程。结果 试验组有效率为 85．00％，对照组为55．26％，两组比较差异有显著性 (P0．01)，试验组的有效率高于对照组。治疗过 程中试验纽 3例、对照纽5例出现不良反应。结论 咪喹莫特乳膏联合卡介茵多糖核酸治疗扁平疣有 较好的疗效，安全性高，不良反应少。 [关键词] 咪喹莫特乳膏；卡介茵多糖核酸；扁平疣 [中图分类号] R752．5 [文献标识码] B [文章编号] 1001—7089(2010)05—0442—02 ClinicalObservationonTreatingVerrucaPlanawithImiquimodCream andPolysaecharideNucleicAcidFraction ofBacillusCalmette-Guerin(BCG-PSN) HUANGMing—huan，QINXiao—feng，HUANGYi，YAOWei (1．DepartmentofDermatology，EastHospital，VongiiUniversity，Shanghai200120，China；2．DepartmentofDermatolo— gY，PutuoHospital，ShanghaiUniversityofTraditionalChineseMedicine，Shanghai200062，China) [Correspondingauthor] QINXiao-feng，Em·ail：qinxiaofeng79@126．com [Abstract] Objective Toobservetheclinicaleffectandsafetyontreatingverrucaplanawithimiquimodcreamandpol— ysaccharidenucleicacidfractionofbacilluscalmette—guerin(BCG—PSN)．Methods Seventy—eightpatients withVelTucaplanaweredividedintotwogroupsatrandom．Fortypatientsinstudygroupweretreatedwith 5％ imiquimodcream topicallyonceanight．whilethirty—eightpatientsintheothergroupweretreatedwith 0．1％ victoriaA acidcreamtopicallyonceanight．Atthesametimeallpatientsweretreatedbyintramuscu— larinjectionofBCG—PSN，3timesperweek，per2mL，eightweeksforonecouFseoftreatment．Results Thetotaleffectiverateofthestudygroupwas85．00％ ，andthecontrolgroupwas55．26％ ．Therewassig— nificantdifferencesbetweenthetworgoups．Inthecourseoftreatment，therewerethreecasesofadversere— actionsinthestudyrgoupandfivecasesofadversereactionsintheothergroup．Conclusion Imiquimod cream combinedwithBCG—PSN isaneffectiveandsafem