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32 1 ( ) Vol. 32 No. 1 2 0 1 1 1 Journal of Xi an Jiaotong University( Medical Sciences) Jan. 2011 基于鸟枪法蛋白质组学和生物信息学技术 对肺鳞癌表达蛋白质谱的分析 1 2 3 2 2 1 南岩东, 杨拴盈 , 田应选 , 霍淑芬 , 杜 洁, 金发光 ( 1. , 710038; 2. , 710004; 3. , 710068) : 目的 , , 方法 6 , ( laser ca ture microdissect ion, LCM) ; ( , shot gun roteomics) ; , 结果 LCM 60 ( ca ) , LCM ca 12 000 , 95% 860 , ; Gene Ontologyc ( GO) Kyoto encyclo edia of genes and genomes ( KEGG) , , 3 , ( mitogenactivated rotein kinase, MAPK) A 1 ( annexin A 1, ANXA 1) B1(high mobility grou rotein B1, H MGPB1) 结论 , : ; ; ; ; ; A1; B1 : R734. 2 :A : 2011) Analysisof expression proteinprofilesof lungsquamouscellcarcinoma basedonshot gunproteomics andbioinformatics technique 1 2 3 2 2 1 NAN Yandong , YANG Shuanying , TIAN Yingxuan , HUO Shufen , DU Jie , JIN Faguang ( 1. De artment of Res iratory Disease, Tangdu Hos ital of Fourth M ilitary Medical U niversity, Xian 710038; 2. De artment of Res iratory M edicine, the Second Affiliated Hos ital, Medical School of Xian Jiaotong U niversity, Xian 710004; 3. De artment of Elderly Res iratory Diseases, Shaanxi Provincial Peo les Hos ital, Xian 710068, China) ABSTRACT: Obj ective To analyze the ex ression rotein rof iles of lung squam ous cell carcinoma ( SQCC) with shot gun roteomics and bioinf ormatics technique and to screen SQC C biomarkers in order to rovide valuable clues for athogenes