大鼠脊髓损伤椎管内蛛网膜下腔持续给药模型的建立.pdfVIP

L ab M ed Clin Decem ber V ol N o Allen d Allen DOI 10 3969 issn2014 24 009 A j Establishment of spinal cord injury rat model of continuous infusion inside subarachnoid space of spinal canal L I U De hua WA N G J ian GA O Zhi ian ZOU L ianshen Z H A N G Gon lian De artment o N euros ur e r q g g g g p f g y the Firs t A f f iliate d H osp ital of Gannan M e dical College Ganz hou J iang x i China Dep artment of Pathology Peop les H osp ital of Ganz hou City Ganz hou J iang x i China Abstract Objective T o establish spinal cord injury rat model of continuous inf usion inside subarachnoid space of spinal canal Methods By using Allens method as a reference rat models of acute spinal canal injury w as prepared to simulate spinal cord injuries similar to clinical trauma Continuous infusion device w as installed inside subarachnoid space in the lesion T he behaviors of rat models w ere observed and the eff ects of this device w as evalua ted by measuring the level of glucose in the drug delivery device Results Rats in the ex perimental g roup suff ered f rom paraplegia in double hindlimb and the tension of muscle below the level of spinal injury w as decreased w ith myodynamia level of rade w ithout reaction to acupuncture and w ith apparent urine retention T he four limbs of g rats in the control g roup f unctioned normally Among all of the rats rat died in day s rats suffered f rom spas tic paraly sis catheter of rats w ere lost or blocked and rats show ed various degree of self mutila