非霍奇金淋巴瘤中MMP_医学论文.docVIP

非霍奇金淋巴瘤中MMP_医学论文 非霍奇金淋巴瘤中MMP_医学论文 【关键词】 明胶酶B；白细胞介素6；淋巴瘤,非霍奇金；免疫组织化学 　　Expressions of MMP 9 and IL6 in nonHodgkins lymphoma and their Relationships with prognosis 　　【Aastract】 AIM: To study the expression of matrix metalloproteinase 9(MMP9) and interleukin6 (IL6) in nonHodgkins lymphoma and its subtypes, and evaluate the relationship between the staining grades of these markers and the prognosis. METHODS: Immunohistochemical SP method was used to detect the expressions of MMP9 and IL6 in the tissues of nonHodgkins lymphoma(n=51). These patients get a follwup of 7 years. RESULTS: The expressions of MMP9 and IL6 were mainly found in cytoplasm of the tumor cells by immunohistochemical SP method, and their expressions in tumor cells were higher than those in reactive hyperplasia of lymphnodes（P＜0.05）. There was statistical significance in the expression of MMP9 among different histological subtypes. The 5year diseasefree survival rates were 66.7%, 50.0%, 35.3%, 0% in patients with grade 0, 1, 2, 3 of MMP9 staining respectively. The 5year diseasefree survival rates were 66.7%, 44.4%, 38.9%, 0% in patients with grade 0, 1, 2, 3 of IL6 staining respectively. CONCLUSION: The expressions of MMP9 and IL6 in tumor cells are higher than those in reactive hyperplasia of lymphnodes. Furthermore, have a correlation with histological subtypes. The staining grades of MMP9 and IL6 are important indexes to estimate the prognosis of nonHodgkins lymphoma. 　　【Keywords】 gelatinase B interleukin6 lymphoma, nonHodgkins Immunohistochemistry 　　【摘要】 目的： 研究MMP9及IL6在非霍奇金淋巴瘤不同组织分型中的表达，探讨染色分级与预后的关系. 方法： 应用免疫组织化学SP法检测51例非霍奇金淋巴瘤组织中MMP9及IL6的表达；并对患者进行随访7 a. 结果： 经免疫组化SP法检测MMP9及 IL6主要表达于肿瘤细胞的胞质中，MMP9及 IL6在非霍奇金淋巴瘤中的表达均高于对照组（P＜0.05）,MMP9的表达在非霍奇金淋巴瘤组织分型间有意义； MMP9染色分级为0，1，2，3级者5 a生存率依次为66.7%，50.0%，35.3%，0%；IL6染色分级为0，1，2，3级者5a生存率依次为66.7%，44.4%，38.9%，0%. 结论： MMP9及IL6在非霍奇金淋巴瘤中的表达均高于对照组,且与非霍奇金淋巴瘤的组织分型相关，是判断非霍奇金淋巴瘤预后的重要指标.　　【关键词】 明胶酶B；白细胞介素6；淋巴瘤，非霍奇金；免疫组织化学 　　0引言 　　细胞外基质和基底膜是肿瘤生长和扩散的基础屏障，而金属蛋白酶及其抑制剂则是细胞外基质代谢的主要调节