a rapid event-related potential (erp) method for point-of-care evaluation of brain function development of the halifax consciousness scanner论文.pdfVIP

Journal of Neuroscience Methods 245 (2015) 64–72 Contents lists available at ScienceDirect Journal of Neuroscience Methods j o u r n a l h o m e p a g e: w w w. elsev /locate/jne umeth Clinical Neuroscience A rapid event-related potential (ERP) method for point-of-care evaluation of brain function: Development of the Halifax Consciousness Scanner Lauren Sculthorpe-Petley a , Careesa Liu b , Sujoy Ghosh Hajra b , Hossein Parvar c , Jason Satel d , Thomas P. Trappenberg c , Rober Boshra c , Ryan C.N. D’Arcy b,∗ a Biomedical Translational Imaging Centre (BIOTIC), IWK Health Centre, Suite 3900–1796 Summer St., Halifax, Nova Scotia B3H 3A7, Canada b Faculty of Applied Sciences, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada c Faculty of Computer Science, Dalhousie University, 6050 University Ave., P.O. Box 15000, Halifax, Nova Scotia B3H 4R2, Canada d School of Psychology, University of Nottingham Malaysia Campus,Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia h i g h l i g h t s • Our method evokes the N100, MMN, P300, ENE, and N400 in about 5 min. • These ERPs were verified at the group level using traditional statistics. • Single subject validation was accomplished using support vector machines (SVMs). • The SVMs successfully classified ERP waveforms with very high accuracy (90%+). • The method overcomes major challenges of translating ERPs from the lab to the clinic. a r t i c l e i n f o a b s t r a c t Article history: Background: Event-related potentials (ERPs) may provide a non-invasive index of brain function for a Received 19 June 2014