姜黄素衍生物的合成和生物活性研究.pdfVIP

第34卷第5期 林　 产　 化　 学　 与　 工　 业 Vol.34 No.5 2014年10月 Chemistry and Industry of Forest Products Oct.2014 doi:10.3969/ j.issn.0253-2417.2014.05.011 Synthesis and Biological Activity of Curcumin Derivatives ∗ KUANG Chun-tao,LI Xiang-zhou ,XUE Hai-peng, DENG Nan,WANG Ling-zhi (College of Material Science and Engineering,Central South University of Forestry and Technology,Changsha410004,China) KUANG Chun-tao　　 Abstract:Four curcumin derivatives were synthesized from curucmin and maleic anhydride by esterification,isomerization,chlorination and esterification. The yields of curcumin derivatives c1-c4 were 80.5%,83.7%, 1 13 81.2% and 85.4%,respectively. Their structures were confirmed by IR, H NMR and C NMR. The antioxidative and antibacterial activities of target compounds c1 -c4 were evaluated. The IC values for scavenging of DPPH·were 164. 14 ± 50 0．82,166.98±0.66,171.97±0.99 and 175.10±2.34 mg/ L,respectively. Their antioxidativeactivitywaslowerthanthat of curcumin (36.22 ±0.22 mg/ L). This proved the importance of phenolic OH. The target compounds c1 -c4 displayed high antibacterial activity,especially compound c4. The minimal inhibiting concentration(MIC) of c4 against Staphylococcus aureus, Escherichia coli,Penicillium sp. andAspergillus niger were0.5,0.5,0.25 and 1.0 g/ L,respectively. There ishopeto obtain antibacterial candidates by curcumin modification with α,β-unsaturated carb