盐酸小檗碱前体脂质体的制备及理化性质研究.pdfVIP

盐酸小檗碱前体脂质体的制备及理化性质研究 杨平林珈好王玉蓉22·23 北京中医药大学中药学院，北京100102 【摘要J目的制备盐酸小檗碱前体脂质体，并对其理化性质进行考察。方法采用薄膜载体沉积 法制备盐酸小檗碱前体脂质体，正交实验优选处方；透射电镜观察形态；马尔文激光粒度仪测 定粒径；高效液相色谱法测定包封率。结果电镜下观察脂质体形态多为圆形或椭圆形，平均粒 径为74l nm，包封率为(29．93士1．32)％。结论该方法制备工艺简单，易于工业化生产。 I关键词l盐酸小檗碱；前体脂质体；脂质体 of and Berberine of Preparation HydrochlorideProlipsomesStudy Its PhysicOchemicalPropenies YANG JiaIla0，、)l，ANG Ping，LIN Yumng+ Schoolofchinese Phamacy’BeijinguniVerS时ofChineseMedicine，Beijing100102，China Tb Berberine and its IAbstracqObjectiveprepare HydrochlorideproliposonlesinVeStigate were onca仃iers． physicochemicalproperties．MethodsProliposomespreparedbyfilm-deposition wasusedtoselectthe fomulation．Theand sizeof OnhogonaIdesign optimum shapeparticle were transmissionelectron andlaserscatter．The proliposomesinVestigatedby microscope wasdeteminedHPLC．ResultsTheBerberine encapsulationefficiency by Hydrochlorideliposome Vesicleswere or undertheelectronic The sizeofthe globularelliptic microscopyaVer乏唱e liposomes was74lnm．The The method was(29．93士1．32)％．Conclusion enc印sulatione塌ciency prep撇tion is and industrialized simpleeasily preparation． Berber．ne 【KeyWordsl hydrochloride；ProIiposomes；Liposomes 小檗碱(Berberine)又称黄连素，常用于治疗肠道炎症。现代研究发现它对于心律失常、高血