口服小剂量西地那非治疗早泄疗效研究_临床医学论文.docVIP

口服小剂量西地那非治疗早泄疗效研究_临床医学论文 口服小剂量西地那非治疗早泄疗效研究_临床医学论文 【摘要】 目的 ：评估持续口服小剂量西地那非、佐洛复、百优解治疗早泄及停药后的疗效。方法：191例早泄病人随机归入3组，接受为期3个月的西地那非、佐洛复、百优解治疗。记录各组病人在治疗前、治疗后以及治疗停药2个月、3个月中国早泄指数评估表（CIPE）评分及性双方对性生活的满意程度。比较各组及组间在各阶段的CIPE评分。结果：3组对象治疗前CIPE分别为（20.77±2.77）、（20.92±2.80）和（20.98±2.53）分，差异无显著性（P gt;0.05）；治疗3个月后分别为（39.22±4.56）、（37.53±3.76）和（37.66±3.63）分；停药2个月后为（31.24±5.25）、（22.85±5.67）和（22.47±4.64）分。停药3个月后西地那非组CIPE为（27.26±5.24）分。3组病人药物治疗3个月后CIPE较治疗前均有显著性升高（P lt;0.01）。组间除佐洛复组与百忧解组差异无显著性外，西地那非组与其它两组间差异均有显著性（P lt;0.05）。药物治疗后，3组对象夫妻性生活满意度明显改善，从高到低依次为：西地那非组、百忧解组、佐洛复组。西地那非组停药2个月后与治疗前CIPE差异有显著性（P lt;0.05）；停药3个月后CIPE仍高于治疗前基线水平，41.5%病人仍具有较好疗效。佐洛复组及西地那非组停药2月后CIPE显著降低，大部分病人症状复发，退出研究，无法继续随访。结论 ：每日口服小剂量西地那非能有效治疗早泄。在效果上，好于左洛复和百忧解，每日口服小剂量西地那非在治疗停药后大部分病人疗效可达2个月以上。 【关键词】 早泄；西地那非；佐洛复；百优解 　　Abstract: Objective: To evaluate the curative effects of low-dose Sildenafil，Sertraline and Fluoxetine for patients with premature ejaculation (PE)， and to observe the effects in each treatment group after drug withdrawl. Methods: A total of 191 PE patients met our study criteria was divided randomly into three groups and then received 3-month treatment of Sildenafil，Sertraline and Fluoxetine， respectively. The curative effects in each group of patients before treatment， after treatment and after withdrawl of 2 months and 3 months using the methods of Chinese index of sexual function for premature ejaculation (CIPE) and the sex life satisfactory degree from both sides were recorded and compared. Results: Before treatment，there was no significant difference of CIPE among Sildenafil-group， Sertraline-group and Fluoxetine-group (20.77±2.77，20.92±2.80 and 20.98±2.53，respectively). After 3-month treatment， the CIPE was 39.22±4.56， 37.53±3.76 and 37.66±3.63 respectively and 2 months after drug withdrawal， the CIPE was 31.24±5.25， 22.85±5.67 and 22.47±4.64 respectively. There was positive difference of CIPE between pre-treatment and post treatment in each group (P lt;0.01). In addition， The significant difference between Sild