口服益生菌对早产儿胃肠动力影响的临床研究_临床医学论文.docVIP

口服益生菌对早产儿胃肠动力影响的临床研究_临床医学论文 口服益生菌对早产儿胃肠动力影响的临床研究_临床医学论文 【摘要】 目的：探讨益生菌对早产儿胃肠动力的影响。方法：将80例早产儿随机分为两组，40例于人工喂养后予口服益生菌，另40例作为对照组根据诊疗常规人工喂养，不加用益生菌。观察两组早产儿体重增长及发生呕吐、胃潴留、腹胀等情况，喂养前和喂养后每周作胃泌素和胃动素的测定。结果：研究组早产儿发生呕吐、胃潴留和腹胀例数分别为8、5、6例，发生率明显低于对照组(分别为13、9、11例);研究组早产儿出生及1～3周体重分别是(2 112±101)g、(2 030±152)g、(2 280±141)g、(2 530±209)g，第3周体重高于对照组，差异有统计学意义(0.05);研究组早产儿喂养前和喂养后1～3周的血清胃泌素分别是(49.33±16.64)、(71.47±24.56)、(78.85±20.64)、(95.61±29.25)pg/mL，胃动素是(175.43±41.26)、(272.14±40.18)、(318.92±37.16)、(360.74±37.93)pg/mL，与对照组相比，研究组3周后的血清胃泌素和胃动素水平有明显增高(0.05)。结论：口服益生菌能减少早产儿喂养过程中呕吐、胃潴留、腹胀的发生，在用药3周后可促进体重增长及促进胃泌素和胃动素的分泌，对早产儿胃肠动力有明显促进作用。 【关键词】 早产儿;益生菌;胃泌素;胃动素 　　[Abstract] Objective: To investigate the effects of probiotics on gastrointestinal motility in premature infants. Methods: Eighty premature infants were divided into 2 groups. Forty cases were treated with probiotics and 40 cases in the control group were treated usually in the routine way. Signs of vomitting, gastric residuals and abdominal distension were recorded， the serum gastrin and motilin were measured. Results: The case numbers of vomitting, gastric residuals or abdominal distension in probiotics group was 8, 5, 6 cases respectively， the rates were significantly lower than those of the control group (13, 9, 11 cases respectively, 0.05). The average weight of probiotics group of the third week was (2,530±209)g, it was higher than that of the control group (0.05). In the third week, the average serum gastrin of the probiotics group was (95.61±29.25)pg/mL, the average serum motilin was (360.74±37.93)pg/mL, both were higher than those of the control group (0.05). Conclusions: Probiotics can promote gastrin and motilin of premature infants when 3 weeks after adiminstration. 　　[Key words] Premature; Probiotics; Gastrin; Motilin 　　近年早产儿出生率及存活率明显提高，但是早产儿胃肠道发育未成熟，喂养后容易出现呕吐、胃潴留、腹胀，导致体重不增、肺部疾病、呼吸暂停甚至生命危险等[1]。近年来，益生菌已用于新生儿治疗腹泻及消化不良、便秘、腹胀、黄疸等[2，3]。有学者对益生菌在早产儿临床应用研究已表明益生菌能促进早产儿肠道正常菌群的定植[4]，本文旨在研究探讨益生菌对早产儿胃肠动力的影响。 　　1 资料与方法 　　1.1 对象 　　本文对象为2006年1月～2