妊娠期高血压疾病患者血浆线粒体偶联因子6的变化_临床医学论文.docVIP

妊娠期高血压疾病患者血浆线粒体偶联因子6的变化_临床医学论文 妊娠期高血压疾病患者血浆线粒体偶联因子6的变化_临床医学论文 作者：张春莲, 赵亚娟, 吕跃峰, 梁江红, 陈双郧 【摘要】 目的:探讨血浆线粒体偶联因子6（mitochondrial coupling factor 6,CF6）与妊娠期高血压疾病的关系。方法:43例妊娠期高血压疾病孕晚期妇女,放免法测定血浆CF6和前列环素I2 (PGI2)的浓度，并与正常晚孕妇女及正常未孕育龄妇女相比较。结果:⑴妊娠期高血压疾病组产前血浆CF6浓度高于正常晚孕组（t＝9.25，P＜0.001），而PGI2的浓度（t＝4.23，P＜0.001）及PGI2/CF6（t＝5.66，P＜0.001）低于正常晚孕组，差异均有显著性。产后1周，两组产妇血浆CF6与PGI2水平均接近于正常未孕妇女，但妊娠期高血压疾病组PGI2/ CF6比值仍然低于正常晚孕组（t＝3.02，P＜0.05）。⑵分娩前血浆CF6浓度及PGI2呈负相关（r＝-0.59，t＝5.8，P＜0.001）。结论:CF6可能通过抑制PGI2合成，参与妊娠期高血压的发生。 【关键词】 妊娠期高血压疾病；线粒体偶联因子6；前列环素I2 Abstract:Objective To investigate the relationship between plasma mitochondrial coupling factor 6 and hypertensive disorder complicating pregnancy. Methods A caseand 21 normal nonpregnant women.Plasma CF6 and PGI2 concentration were measured with radioimmunoassay. Results ⑴Plasma concentration of CF6 in hypertensive disorder complicating pregnancy group was higher than that in normal pregnant group before delivery (t=9.25, P＜0.001), while the concentration of PGI2 (t=4.23,P＜0.001) and PGI2/CF6 (t=5.66,P＜0.001) was lower than normal pregnant women.Postpartum a week, the concentration of CF6 and PGI2 in maternal plasma was closer to the normal non PGI2/ CF6 in hypertensive disorder complicating pregnancy was still lower than normal pregnant women (t=3.02, P＜0.05). ⑵There was a negatively correlated between CF6 and PGI2 level before delivery (r=-0.59, t=5.8,0.001). Conclusions CF6 may inhibit PGI2 sythesis,and participate in hypertensive disorder of pregnancy in patients with hypertension. Key Words: Hypertensive disorder complicating；Mitochondrial coupling factor 6;PGI2 　 妊娠期高血压疾病是妊娠期特有的疾病，严重危害孕产妇的健康，是导致母婴死亡的主要原因，其发生机制不明。前列环素I2 (PGI2) 具有强效扩血管和抑制血小板凝集作用, 其合成减少与妊娠期高血压疾病有关。线粒体偶联因子6（mitochondrial coupling factor 6,CF6）是新发现的缩血管活性肽，已经被证明与高血压的发生有关[1-2]。CF6能够抑制磷脂酶A2的活性，减少花生四烯酸的释放，从而减少PGI2的合成，是体内唯一的内源性PGI2合成抑制剂。本研究测定CF6在妊娠期高血压疾病患者血浆中的变化，以探讨其在妊娠期高血压疾病发病中的意义。 1 资料与方法 1.1 对象 妊娠期高血压疾病组：所有产妇均来自2005年9月-2006年3月我院产科住院病人(初产妇，既往无高血压、肾脏疾患病史)。根据第六版妇产科教材，确诊为妊娠期高血压疾病患者4