婴幼儿急性呼吸道感染沙眼衣原体检测及临床分析_临床医学论文.docVIP

婴幼儿急性呼吸道感染沙眼衣原体检测及临床分析_临床医学论文 婴幼儿急性呼吸道感染沙眼衣原体检测及临床分析_临床医学论文 作者：赵艳玲 孙利伟 刘愉 包进 邓琳菲 王承训 贺岩 李丽红 【摘要】 目的 了解婴幼儿急性呼吸道感染与沙眼衣原体(CT)的关系。 方法 应用荧光定量聚合酶链反应(PCR)方法检测2008年在本院住院的急性呼吸道感染婴幼儿鼻咽分泌物中CT份，分析CT阳性患儿的临床表现，并与90例非CT性支气管肺炎的临床表现进行比较。 结果 婴幼儿急性呼吸道感染CT阳性比例为5.3 %(96/1 827);CT性急性呼吸道感染均诊断为肺炎，CT性急性呼吸道感染肺炎发生比例高于同期非CT性小儿急性呼吸道感染中肺炎的发生比例，差异有统计学意义(0.001);≤3月龄婴儿中CT性急性呼吸道感染比例为20.99 %(85/405),4～36个月年龄组为0.8 %(11/1 422),二者比较,差异有统计学意义(0.001);CT感染患儿住院首发症状为咳嗽者占66.7 %(64/96)，喘憋者占22.9 %(22/96);临床有喘憋、紫绀、干咳症状和体征者分别占89.6 %(86/96)、44.8 %(43/96)、40.6 %(39/96);X影像学改变有肺野内带条状影体征者89.6 %(86/96)，合并结膜炎、出现心衰者分别占89.6 %(86/96)和25.0 %(24/96);平均住院日为(10.4±2.4)d，较普通婴儿肺炎住院时间(7.6±1.3)d长。 结论 CT感染是引起婴幼儿急性呼吸道感染的病原之一;主要引起下呼吸道感染;多见于3个月以内婴儿;临床易发生干咳、喘憋、紫绀症状和体征;易合并心衰;病程较长。 【关键词】 婴幼儿; 急性呼吸道感染; 沙眼衣原体 　　【Abstract】 Objective To investigate the relationship between Chlamydia trachomatis and acute respiratory infection in infants. Methods Fluorescence quantitative polymerase chain reaction (FQho were diagnosed with acute respiratory infection in 2008, and to associate with the clinical manifestation of the patients with positive results. Results The positive rate of Chlamydia trachomatis infection was 5.3 % (96/1 827); 88.5 % (85/96) of the patients were younger than 3 months of age, and 99.0 % (95/96) of the infants were younger than 6 months of age. The onset symptom was cough in 66.7 % (64/96) of the patients, wheeze in 22.9 % (22/96). 89.6 % (86/960 of the infants showed wheeze, 44.8 % (43/96) cyanosis, 40.6 % (39/96) light cough, and 89.6 % (86/96) patch shadow in lung Xray imaging, 25.0 % (24/96) conjunctivitis, and 20.8 % (20/96) heart failure. The average course of the disease was (10.4 2.4) days, longer than the common pneumonia. Conclusion Respiratory infection caused by Chlamydia trachomatis is characterized by lower respiratory tract infection. Cyanosis, cough, wheeze and heart failure are among the most common symptoms. 　　【Key words】 Chlamydia trachomatis; Acute respiratory infections; Diagnosis 　　婴幼儿呼吸道感染是婴幼儿时期最常见的疾病,也