参芍胶囊对急性心肌梗死血管再通后内皮功能的影响.pdfVIP

第28卷 第2期 医 学 研 究 与 教 育 Vol.28 No.2 2 0 1 1 年 4 月 Medical Research and Education Apr.2011 参芍胶囊对急性心肌梗死血管再通后内皮功能的影响 1 2 2 2 韩璇 ，王乾一 ，李亚芹 ，刘勤勤 （1.河北大学基础医学院，河北 保定 071000；2.河北大学附属医院，河北 保定 071000） 摘要： 目的 观察参芍胶囊对急性心肌梗死溶栓治疗后患者血管内皮细胞功能的影响。 方法 将40名冠心病急性心肌梗死溶 栓治疗后的患者（经心电图及临床证实均溶栓有效，血管再通）随机分成对照组与参芍治疗组，对照组给予常规治疗， 治疗组除常规治疗外同时给予参芍胶囊口服， 治疗30d，用药前后分别测定各组患者血清中的一氧化氮（NO）含量和一 氧化氮合酶（NOS）活性，同时测定超氧化物歧化酶（SOD）活性和丙二醛(MDA)水平。 结果 治疗后对照组与参芍治疗 组NO水平、NOS及SOD活性均较治疗前升高，而MDA的水平较治疗前降低，但是参芍治疗组各项指标改善情况优于对照 组。 结论 参芍胶囊可以改善急性心肌梗死溶栓治疗后血管内皮细胞功能，从而作为冠心病康复治疗的有效药物。 关键词：参芍胶囊 ；急性心肌梗死；内皮细胞功能 中图分类号：R285 文献标志码：A 文章编号：1674-490X(2011)02-0059-03 Effects of Shenshao capsules on vascular endothelium function in patients with acute myocardial infarction after thrombolysis therapy 1 2 2 2 HAN Xuan , WANg Qianyi , Li Yaqin , Liu Qinqin (1. College of Basic Medical Science of Hebei University, Baoding 071000, China; 2.Affiliated Hospital of Hebei University, Baoding 071000, China) Abstract: Objective To investigate the effects of shenshao capsules on vascular endothelial function in patients with acute myocardial infarction after thrombolysis therapy. Methods 40 patients with acute myocardial infarction (AMi) (after thrombolysis therapy) were divided into experimental group and control group, control group was given conventinal drugs, experimental group was given shenshao capsules and conventinal drugs. After treatment, both NO and NOS, SOD and MDA in serum were dertermined. Results The level of NO, NOS and SOD after treatment were higher than that before treatment, the level of MDA after treated were lower than before treated, but the improvements of every index of shenshao capsules tr