慢性酒精中毒视觉诱发电位的改变_临床医学论文.docVIP

慢性酒精中毒视觉诱发电位的改变_临床医学论文 慢性酒精中毒视觉诱发电位的改变_临床医学论文 【关键词】 慢性酒精中毒 Visual evoked potential in chronic alcoholism ［Abstract］ Objective In order to evaluate the effect of alcohol consumption and the effect of abstinence on central nervous system generated parameters,we performed pattern visual evoked potential （PVEP） recordings on chronic alcoholics.Methods The study was conducted on 40 patients diagnosed as chronic alcoholics according to DSM IV criteria.They were aged mean:42,and had history of alcohol abuse for at least six years （mean:21）.In order to test the effect of abstinence period on P100 latency values,alcoholics were divided into two subgroups.Group I （Gr Ⅰ） consisted 24 alcoholics who had been abstinent for less than 30 days （mean:14）,and Group Ⅱ （Gr Ⅱ） consisted 16 alcoholics who had been abstinent for more than 30 and less than 76 days （mean:38）.Results 15% of the patients demonstrated abnormal VEP results at least in one tested eye.The mean P100 latency of Gr Ⅰ and Gr Ⅱ was 101 and 102 milliseconds （ms） respectively;And when compared to normal controls the difference was statistically significant （P:0.016,P:0.009）.Conclusion Abnormal VEP in asymptomatic chronic alcoholics suggests that they may be useful in the detection of early changes and in following the progress of patients with the disorder. ［Key words］ chronic alcoholism;pattern visual evoked potential （PVEP）; P100 amplitude; P100 latency 慢性酒精中毒因长期大量饮酒所致,戒酒后病情可改善,酒精中毒在国外是列于心血管疾病、癌症以后,占第三位的最严重的3类疾病之一［1］。随着物质生活水平的改善,近年来酒精依赖和慢性酒精中毒患者人数日益增多,导致神经系统弥漫性损害，但是很多患者并不表现出任何酒精中毒的症状和体征，尤其是年轻的患者或是疾病的初期［2］。然而有许多研究显示长期饮酒的患者会出现中枢神经系统结构和功能的改变［3、4］。虽然有些患者临床表现较少，但是通过神经生理学和神经放射学方法进行检测可以看到中枢神经系统的确有结构和功能方面的改变［5］。早在1970年就有学者对长期饮酒者进行调查，采用诱发电位的方法研究发现神经系统发生功能性衰退［6］。 诱发电位可以为了解中枢神经系统结构是否光整提供相应的信息，同时在脱髓鞘脑干代谢性或感觉器官病变的诊断中有很大的临床使用价值［7］。因此，为了了解长期饮酒对视力的影响，对图形视觉诱发电位（PVEP）进行了检测，现报告如下。 1 资料与方法 1.1 分组 选取确诊为慢性酒精中毒的40例男性患者，年龄29～61岁，平均（42±6）岁。受试者均有至少6年的酗酒史，平均年限为（21±9）年。在测试前患者均经过至少7天的解毒治疗，由此排除了一些如体温降低等相关的影响因素。解毒的疗效通过每天酒精比重计进行了解。为了解不同戒酒周期对PV