酵母蛋白质网络的动力学性质.pdfVIP

90 # * 1, 2 1, 2 1, 2 1, 2,­ 1, 3 李方廷 吕 莹 龙 涛 欧阳颀 汤 超 ( 1 100871) ( 2 100871) ( 3 NEC Laboratories America, 4 Independence Wa , Princeton, NJ 08540, USA) - - DNA . ( bud- ding east saccharom ces cerevisiae) - , ( cell c cle and life c cle) , . : , 94% G , 1 ; , G G , 1 1 / 0 . , , Dynamical properties of protein networks in yeast 1, 2 1, 2 1, 2 1, 2,­ 1, 3 LI Fang-T ing LU Ying LONG T ao OUYANG Qi TA NG Chao (1 Centref or Theoretical Biology, Peking University, Beij ing 100871, China) (2 School of Physics, Peking University, Beijing 100871, China) (3 NECLaboratories A erica, 4 Independence Way, Princeton, NJ 08540, USA) Abstract Protein-protein and protein-DNA interactions in living cells constitute molecular d namic net- works that govern various cellular functions. Based on recent studies of budding east and other related litera- ture, we have established the protein network governing the cell c cle and life c cle processes. Here we report our d namical anal sis of the cell-c cle network of budding east using a discrete two- state model. Our stud reveals important properties of the network: ( 1) almost all ( ~ 94%) initial protein states evolve to the sta- tionar state G , making it a global attractor; ( 2) the d namical paths to G for these initial states are through