8汉字处理相关大脑皮层区功能磁共振成像.pdfVIP

198 2002 3 36 3 Chin J Radi l, March 2002, V l 36, N . 3 马林 唐一源 王岩 李德军 翁旭初 张武田 庄建程 胡小平 (fMRI) , fMRI 8 , fMRI MRI 2 ( 1. 5 T GE Signa H riz n 1. 5 T Siemens Visi n) Br ca Wernicke t ( t = 0. 35, P 0. 05) , 2 MRI fMRI , MRI , ; ; ; , Mapping cortical areas associated with Chinese word processing with functional magnetic resonance imaging * MA Lin , TANG Yiyuan, WANG Yan, LI Dej un, WENG Xuchu, ZHANG Wutian, ZH UANG Jiancheng , H U * Xiao ing . De artment of Radiology, PLA General Hos ital, Beij ing 100853 , China Abstract Objective T identify the c rtical areas engaged during Chinese w rd pr cessing with functi nal magnetic res nance imaging ( fMRI) and t examine the reliability and repr ducibility f fMRI f r l calizati n f functi nal areas in the human brain. Methods fMRI data were c llected n 8 y ung, righ-t handed, native Chinese speakers during perf rmance f Chinese syn nym and h m ph ne judgement tasks n 2 different clinical MRI systems ( 1. 5 T GE Signa H riz n and 1. 5 T Siemens Visi n) . A cr ss c rrelati n analysis was used t statistically generate the activati n map. Results Br cas area, Wernickes area, bilateral extrastriate, and ventral temp ral c rtex were significantly activated during b th syn nym and h m ph ne tasks. There was essentially n difference between results acquired n 2 different MRI systems. Conclusion fMRI is feasible f r l calizing c rtical areas critical f r Chinese language pr cessing in the human brain. The results are reliable and well repr ducible acr ss different clinical MRI systems. Key words Language test; Semantic differentiati n; Magnetic res nance imaging; D minance, cerebral [ 3] Wada 40 [ 1] ,