强化降脂治疗对急性脑梗死患者血清炎性因子IL_6及MMP_3的影响.pdfVIP

2010 5 32 10 H ebeiM ed ical Journal, 2010, Vol 32 M ay No. 10 1197 # # IL-6MMP-3 肖家平 = 探讨短期内使用阿托伐他汀强化降脂对急性脑梗死患者血清高敏 C- 应蛋白 ( hs-CRP)白介素-6( IL-6)及基质金属蛋白酶-3(MMP-3) 的影响, 以了解其对脑梗死炎症抑制和颈动脉斑 块稳定作用 120例急性脑梗死患者患者根据颈动脉超声检查结果分为颈动脉稳定斑块组和颈动 脉易损斑块组, 每组 60例抽血检查后随机分为常规治疗组 (阿托伐他汀 10 mg /d, 口服) 和强化治疗组 60例 (阿托伐他汀40 mg /d, 口服), 每组 60例所有患者药物治疗前和治疗后2周检测血脂及hs-CRPIL- 6和MMP-3等指标 治疗前常规治疗组和强化治疗组中血脂及 hs-CRPIL-6和 MMP-3水平差异无 统计学意义 ( P 0. 05)治疗后 2周, 强化治疗组中2亚组(尤其是易损斑块组)血清LDL-Chs-CRPIL-6 和MMP-3三项指标水平明显低于常规治疗组, 差异有统计学意义 ( P 0. 01) 阿托伐他汀强化降 脂能迅速降低脑梗死患者的血清炎性因子水平, 具有抑制炎症和斑块稳定作用 = 脑梗死; 阿托伐他汀; 白介素-6; 基质金属蛋白酶-3 = R 446. 11 = A = 1002- 73 6( 2010) 10- 1197- 03 Effect of high-dose atorvastatin on the inflammatory factors including interleukin-6 and marix metalloproteinases-3 in acute stage of cerebral infarction X IAO J iap ing. D ep artm ent of N eurology, The Ffi th H osp ital of Wuhan C ity, Wuhan 430050, China = Abstract Objective To observe the effect of short-term h igh-dose atorvastatin on the inflamm atory factors includ ing h igh sensitivity C-reactive protein ( hs-CRP), interleuk in-6 ( IL-6) and m arixm etalloproteinases- 3 (MMP-3) in patientsw ith acute stroke, and to explore the effects of atorvastatin in inh ib iting inflamm ation and stabilizing the atherosclerosis p laque. M ethods 120 patients w ith acute cerebral infarction were d ivided into carotid vulnerable plaque group and carotid stable p laque group according to the exam ination results of carotid B-m ode u ltrasonography. The 60 patients w ith carotid vu lnerable plaques and the other 60 patients w ith carotid stable plaques were random ly d ivided into conventional group ( n = 60) and h igh-dose atorvastatin group ( n = 60). The patient