中西医结合治疗重症急性胰腺炎不预防性使用抗生素临床研究-3300.docVIP

中西医结合治疗重症急性胰腺炎不预防性使用抗生素的临床研究patients with severe acute pancreatitis with integrated traditional Chinese and Western medicine therapy under non-preventive use of antibiotics [摘要] 目的:探讨中西医结合重症急性胰腺炎患者不预防性使用抗生素后的影响。方法:重症急性胰腺炎患者试验组和对照组两组并发症率结果:两组并发症及率,不存在统计学。结论:继发感染的发生率 【关键词】中西医结合; 重症急性胰腺炎;抗生素;感染 Objective:To the prognostic effects on patients with severe acute pancreatitis(SAP), who accept the integrated traditional Chinese and Western medicine therapy but without antibiotics in treatment. Methods: Divide the 60 SAP patients randomly into experimental group(30cases included)and control group (30cases included). While accept the same treatment, experimental group use the antibiotics preventively in addition. Observe the difference of complications incidence, operating conversive rate, hospitalization rate and mortality between the two groups. Results: There were no statistical differences in the course of disease, sex, age and other basic date among these 60patients. The complications incidence, operating conversive rate, hospitalization rate and mortality incidence rates did no have statistical differences neither. Conclusion: The study cannot confirm that the incidence rates of secondary infection and mortality reduced by the preventive use of antibiotics. Keywords: integrated traditional Chinese and Western medicine therapy; severe acute pancreatitis; antibiotics; infection 近年来，随着急性发病率我们采用中西医结合的方法治疗SAP取得了显著的疗效[1][2]。临床上采用预防性抗生素,以降低胰腺及胰周的感染不合理应用抗菌素的后果,二重感染本研究旨在通过临床随机对照试验1 资料与方法 1.1 一般资料 随机抽取我院收治的60名急性胰腺炎患者，组和对照组各30名。组男性12名，女性18名，对照组男性14名，女性16名。患者平均年龄.3岁，病程平均.2年。两组患者均符合急性胰腺炎的诊断标准在病程性别和年龄等方面无显著统计学差异在研究中进行比较。 在急性胰腺炎基础上有以下之一者[]:(1)脏器功能障碍;(2)Ranson评分≥3分;(3)急性生理和慢性健康评价指标Ⅱ评分≥8分;(4)Balthazar CT分级Ⅱ级或Ⅱ级以上。 1. 治疗方法 患者入院后医治疗具有防治感染或协同防治感染的,能改善腹腔脏器血供、促进胃肠蠕动、保护肠道屏障功能菌毒在治疗的同时抗生素治疗后期如出现感染细菌培养及药敏试验选用敏感抗生素 1.4 统计学方法 计量资料数据以x±s表示。应用SPSS 10.0 for Windows软件,进行t检验和χ2检验,检验水准α=0.05。2 结果 n） 并发症的发生率（%） 中转手术率（%） 住院率（%） 死亡率（%） 对照组 30 20.33 16.67 100 3.33 实验组 30 23.33 13.33 100 6.67 注：与对照组相比，