探讨β-2肾上腺素能受体基因多态性和散发及家族群发支气管哮喘的相关性.docVIP

探讨β-2肾上腺素能受体基因多态性与散发及家族群发支气管哮喘的相关性 [摘要] 目的：探讨研究β-2肾上腺素能受体基因多态性与散发性及家族群发性支气管哮喘的相关性。方法：回顾性分析散发性支气管哮喘和家族群发性支气管哮喘患者各84例的β-2肾上腺素受体基因多态性，并将其与健康组84例体检者进行比较，对其进行总结分析，探讨其基因多态性对发病的影响。结果：三组患者β-2肾上腺素受体基因16位基因型为Arg/ Arg的比例相近，而对于基因型Gly/Arg频率，仅家族群发性哮喘组患者中出现的频率明显低于健康组（P0.05），散发性哮喘组与健康对照组频率相当。在基因型Gly/Gly频率比较中，二组哮喘组患者的基因频率均明显高于健康对照组（P0.05），且家族群发性哮喘组患者的发生率偏高程度更为明显。对该基因16位等位基因频率统计，可知，两组哮喘患者的Gly频率明显升高较健康对照组（P0.05），但二组内无统计学差异（P0.05）。β-2肾上腺素受体基因27位三种Gln/ Gln、Gln/ Glu和Glu/ Glu在三组中出现的频率相当，无统计学差异。对该基因27位等位基因频率统计，可知，三组患者的Glu、Gln频率均相当，无统计学差异（P0.05）。结论：哮喘患者的β-2肾上腺素受体基因多态性具有一定的普遍性，且16位Gly基因频率的明显升高，可能是哮喘发生，尤其是家族群发性哮喘发生的重要影响因子，但27位基因多态性的影响还不明确。 【关键词】β-2肾上腺素能受体； 基因多态性；支气管哮喘 The discussion of the β-2 adrenergic receptor gene polymorphism correlation between the sporadic and familial bronchial asthma Li Zhengxing? Jiang GuoqiangDepartment of Respiratory,The Zhongjiang Peoples Hospital, Sichuan Province,?618100, China [Abstract] Objective: To explore the correlation of the β-2 adrenergic receptor gene polymorphism among the patients who was sporadic and familial bronchial asthma. Methods: The retrospective analysis was executed, in which the sporadic and familial bronchial asthma bronchial asthma were analyzed. The two group both had the 84 cases. At the same time, the 84 cases healthy volunteers were selected as the contrast. The β-2 adrenergic receptor gene polymorphism from all the patients and volunteers were compared to explore its impact on the incidence of genetic polymorphisms. Results: The Arg/Arg genotype of the β-2 adrenergic receptor gene at the 16 locus occupied the similar proportion, while Gly/Arg ration from the familial asthma patients was significantly lower than the frequency of healthy group (P0.05) and sporadic asthma group was agreed with the healthy control group. In genotype Gly / Gly frequency comparison, the two groups of patients with asthma were significantly higher than the healthy control group (P 0.05), and familial asthma patients showed the more obvious