聚乳酸的降解性能及其微球剂的研究.pdfVIP

·实验研究 · 聚乳酸的降解性能及其微球剂的研究 * 1 1 1 2 2 ( 杨 帆 ,陈一岳 ,林 茵 ,赵耀明 ,麦杭珍 1 广东药学院 ,广州市 510224 ;2 华南理工大学材料学院 ,广 州市 510640) 中图分类号:R965 文献标识码 :A 文章编号 : 1001- 0408 (2002) 05 - 0263 - 03 摘要 : 目的:研究聚乳酸的降解性能和制备聚乳酸红霉素微球。方法:将聚乳酸薄膜置于模拟体液中水解 ,用正交设计优选微球制备 工艺。结果 : 分子量高的降解比分子量低的慢 , 消旋聚乳酸的降解比左旋聚乳酸的快。微球形态圆整 , 性质稳定 , 平均粒径为 ( ) ( ) 1098 ±0 15 m ,体外释药符合 Hi guchi 方程 Q = 28 067 + 3 8 515 T 1/ 2 ,r = 0 9 834 。结论:聚乳酸的降解与分子量和构型有 μ 关 ,微球具有明显的缓释作用和满足肺靶向药物的要求。 关键词 :聚乳酸;降解性能;微球 Study on the Biodegradabil ity of Polylactic Acid and the Pre paration of Its Microspheres YAN G Fan ,CHEN Yi yue ,L IN Yin ( Guangdong College of Pharmacy , Guangzhou 510224) ZHAO Yaomin g , MA I Hangzhen ( College of Materials , Sout h China U niversit y of Technolo gy , Guangzhou 510640) ABSTRACT : OBJ EC T IV E : To st ud t he biode radabilit of ol lactic acid and re are it s micros heres containin er y g y p y p p p g y t hromycin M E THODS : The polylactic acid film was de graded in vit ro The ort ho gonal desi gn was used to op timize t he tech nolo gy of p rep aration of microsp heres R ESUL TS : The de gradable sp eed of polylactic acid wit h hi gh molecular wei ght was faster t han t hat wit h low molecular wei ght The degradable sp eed of PDLLA was faster t han t hat of PLLA The microsp heres were stable in qualit y and regular in external form The avera ge p article size was ( 1098 ±0 15) m The in vit ro release p rop μ erties could be exp ressed by t he Hi guchi ’s equation