证候动物模型对中医药研究的意义及方法学探讨_崔轶凡.pdfVIP

第 27 卷 第 12期 Vol. 27 N o. 12 2 0 09年 12月 CH INESE ARCH IVES OF TRAD IT OI NAL CH INESE M ED CI INE Dec. 2 0 0 9 崔轶凡, 王庆国 (, 100029) : 证候动物模型在中医证候以及中药药理研究中都有着重要 意义, 其发展水平 滞后已经成为中医 药现代化 瓶颈以目前 研究水平来看, 病证结合 动物模型是最适合中医药研究 技术平台病证结合动 物型既要以中医理论为指导, 又必须能够以科学 实验方法去证实在研究中认为, 通过流行病学调查和无监督 方法, 建立疾病 证候诊断标准, 可以保证纳入病例 客观性以此为标准, 从多种证候模型建立方法中选择出 与临床最吻合 一种再通过方证相应(/ 证实0 ) 及方证相左(/ 证伪0 ) 对动物模型 疗效反证, 评价其可靠性 这是病证结合动物模型 建立 新思路与新方法, 并为提高临床疗效及疾病实验研究提供依据 : 证候动物模型; 病证结合模型; 研究意义; 建立方法 : R- 33 : A : 1673- 7717( 2009) 12- 2525- 03 The V alu e of D isease and Z heng H ou An im a lM odel to T rad itional Ch in ese M ed icine and M ethodological Conference CU IY i-fa , WANG Q i g-guo ( Beiji g U iversity of Traditio alChi eseM edici e, School of BasicM edici e, Beiji g 100029, Chi a) Abstrac:t Zhe g hou a mi alm odel has the mi porta t value to trad itio al Chi ese m edici e ( TCM ). H ow ever, its backw ard i developm e t is a chock poi t of moder izatio of TCM. At prese t, d isease a d zhe g hou a mi alm odel is them ost su itab le tech ological p latform to TCM. W e th i k that by the methods of ep idem iology a d u supervised a aly- sis, we ca set up zhe g hou d iag osis sta dardwh ich w ill e sure objectivity of cli ical cases. A ccordi g to th is sta d- ard, w ew ill select o e a mi alm odelwh ich m ost closely meet cli ic reality a d estmi ate it by agreem e t a d d isagreeme t of prescriptio a d zhe g hou( verify a d falsify). This disease a d zhe g hou a mi alm odel are ot o ly u der the leadi g of TCM theory, but also ca be verified by expermi e talmethods. It w ill be basis of cli ical effective ess a d expermi e - tal research of TCM. Key w ords: zhe g hou a mi alm o