MicroRNAs参与调控中枢神经系统的发育及脊髓损伤修复.pdfVIP

中国细胞生物学学报 Chinese Journal of Cell Biology 2014, 36(6): 832–835 DOI: 10.11844/cj cb.2014.06.0385 MicroRNAs参与调控中枢神经系统的 发育及脊髓损伤修复 1 1 1 1 2 1 邹红军 高 鑫 张 健 丁 亚 龚爱华 刘锦波 * 1 2 ( 苏州大学附属第三人民医院骨科, 常州2 13003; 江苏大学基础医学与医学技术学院, 镇江2 12013) 摘要 microRNAs(miRNAs)不仅参与神经系统的生长发育、功能完善, 还参与脊髓损伤病 理及损伤后修复过程。miRNAs能使中枢神经系统按正确的时序性和空间性顺序进行发育和分化, 在维持生物体记忆及生物钟方面起着重要作用。miRNAs异常表达同脊髓损伤病理过程相关。目前, 体内及体外实验均已证实, miRNAs不仅能够维持神经干细胞增殖, 而且可以促进神经元轴突伸长, 从而为脊髓损伤的治疗带来新的治疗策略。 关键词 microRNAs; 中枢神经发育; 干细胞增殖; 轴突伸长; 脊髓损伤 The Roles of MicroRNAs in CNS Development and Regeneration of Spinal Cord Injury 1 1 1 1 2 1* Zou Hongjun , Gao Xin , Zhang Jian , Ding Ya , Gong Aihua , Liu Jingbo 1 ( Department of Orthopedics, the Third Affiliated Hospital of Suzhou University, Changzhou 213003, China; 2School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China) Abstract MicroRNAs (miRNAs) are RNA molecules composed of 20~24 nucleotides which have key roles in normal CNS development and functions, as well as in diseases. miRNAs express in temporal and spatial patterns during the development and differentiation of CNS, and play key roles in maintaining biological memory and clock. Moreover, the abnormal expression of miRNAs may be related to pathological process of spinal cord injury. Emerging evidences suggest that miRNAs can not only maintain neural stem cell proliferation, but also pro- mote neuron axon elongation. So, miRNAs can provide new treatment strategies f