周围神经损伤后外源性神经生长因子及睫状神经营养因子对神经元的保护作用.pdfVIP

32 Chi J Microsurg Feb, . 1997, Vol. 20 No. 1 周围神经损伤后外源性神经生长因子及 睫状神经营养因子对神经元的保护作用 许家军　何　成　宋田斌　赵小林　王成海　姜宗来　路长林 : ( NGF) ( CNTF) : , SAL ( ) NGF CNT F 2, ( CHE ) (ACP) : , SAL CHE , ACP ; NGF , ; CNTF NGF : , NGF , CNTF PROTECTIVE EFFECT OF EXOGENOUS NERVE GROWTH FACTOR AND CILIARY NEU- , ROTROPHIC FACTOR ON NEURONS AFTER SCIATIC NERVE INJURY IN RAT X u J iaj un H e Cheng , S un Tianbing , et al . Dep ar tment of A natomy , S econd M ilitary M edical Univ er ity , Shanghai, 200433 ABSTRACTObj ective: Protective effect of exoge ous NGF a d CNT F o euro s w as studied . : - , 0. 9% , after peripheral erve i jury Meth ds Aft er silico e tubulizatio of sciatic erve i rat sali e NGF or CNT F solut io was i jected i t o silico e chamber duri g erve repair a d subcutis every day af- ter surgery . E zym e histochemistry was used to show CHE, ACP act ivity of spi al mot o euro s i spi al segme t s a d se sory euro s i spi al ga glio s combi ed w it h com puter image a alysis. Re- : , sults Compared w ith the co trol side both e zymes activity sig ifica tly cha ged i both euro s i SAL group. Both e zymes activity sig ifica tly cha ged i mot o euro s, but ot i se sory euro s i NGF group. The results i CNTF group were co trary to that i NGF group. C nclusi ns:T hese results , suggest that exoge ous NGF protects se sory euro s a d exoge ous CNT F mot o euro s after periph- eral erve i jury . KEY WORDSPeripheral erveI juryNeurotrophic fact ors , 1 , (