国产和进口人用纯化Vero狂犬疫苗的免疫效果研究.pdfVIP

1168 CHINA T ROPICAL MEDICINE Vol15 No16 September 2005 2005 5 6 [ ] X Vero 耿艺介, 汪武新, 谢远辉, 高世同, 吴双, 黄达娜, 张仁利 摘要: 目的 评价目前我国常用的国 狂犬疫苗和进口人用纯化Vero 狂犬疫苗的免疫效果, 为临床选择经济有 效的狂犬疫苗提供依据 方法 用酶联免疫吸附法( ELISA) 检测分别经长春辽宁和法国维尔博三种狂犬疫苗全程 免疫接种的300 名暴露后接种者的血清狂犬病毒中和抗体, 分析比较其抗体阳转率实际抗体水平及接种副反应 结果 排除年龄免疫- 检测时间间隔等干扰因素的影响后, 三种人用纯化Vero 狂犬疫苗不仅抗体阳转率( 分别为 9310% , 9312% , 861 7% ) 和抗体浓度( 分别为16121 ? 51 27, 15193 ? 4135, 15189 ? 61 17 IU / ml) 没有统计学差异, 在接种副 反应方面的差别也没有显著性 结论 国 与进口人用纯化Vero 狂犬疫苗的免疫效果具有较好的可比性, 因其价 格低可以在临床推广使用 关键词: 狂犬疫苗 免疫效果 副反应 中图分类号: R45712 文献标识码: A 文章编号: 1009 - 9727( 2005) 06- 1168- 03 Study on the immune effect of homebred rabies vaccines and import rabies vaccines1 GENG Yi- jie, WANG Wu - xin, XIE Yuan - hui, et al1 ( Shenzhen Municipal Center for Disease Control and Prevention , Shenzhen 518020, Gu angdong, P1 R1 Chi- na) Abstract:Obj ective To evalvate the immune effect of homebred rabies vaccines and import rabies vaccines and provide scien- tific basis f or clinic selection of qualified vaccine1 Methods IgG antibody against rabies w as detected from 300 exposed subjects immunized w ith three kinds of homebred and import rabies vaccines by using ELISA1 The antibody and sideseff ects w ere observed and compared among the three kinds of rabies vaccines1 Results Exclusion of the influence of age, immunization time no significient diff erences on immune eff ect among ChangChun rabies vaccines, LiaoNing rabies vaccines and France rabies vaccines. The antibody positive conversion rates are 9310 % , 9 31 2% and 8617 % and the antibody concentrations are 16121? 5127 , 15193? 4135 , 15189