阿尔茨海默病和脑源性神经营养因子的关系.pdfVIP

Vo.l 21 No. 2 Janua ry 2010 HAI A MEDICAL JOUR AL 56 2010 21 2 # # 张 敏 ( 广西壮族自治区南宁市社会福利医院, 广西 南宁 530003) = (A lzhemi er d isease, AD) ( B rain- derived neurotrophic factor, BDNF), BDNF 200 1 - 2008 5 24AD 2 , , 12AD BDNF, (MMSE ) AD BDNF ( t= - 4. 927, P = 0. 000), BDNF MMSE (F = 5 . 0 7, P = 0. 000), (F = 1. 7, P = 0. 211) BDNF AD , BDNF AD = ; ; ; = R74 1 = A = 1003) 350( 2010) 02) 015) 03 Relationship between Alzheimer disease and brain- derived neurotrophic factor. ZHANG M in. SocialWel- fare Hospital of Nanning C ity, Nanning 530003, Guangxi, CH INA = Abstract Objective To study the variation of brain- derived neurotrophic factor ( BDNF) from cerebro- spinal flu id and the therapeutic efficacy of exogenous BDNF on A lzhemi er disease( AD). M ethods The inpatients of 24 AD and 2 cerebral infarction of undementiaw ere chosen from January 200 toM ay 2008, and the BDNF from cerebrosp inal fluidw ere detected by enzym e- linked mi m unosorbant assay. The therapeutic efficacy of 12 AD pa- tients injected exogenous BDNF via vertebral canalw as evaluatedw ith the d ifference of M ini- M ental State Exam i- nation (MM SE) before and after treatm ent. Results The concentration of BDNF from cerebrospinal fluid at AD pa- tientsw as significantly lower than that of cerebral infarction of undem en tia( t = - 4. 927, P = 0. 000), and the exoge- nous BDNF w as ab le to elevate theAD scores ofMMSE (F = 5 . 0 7, P = 0. 000) w ith