11_HSD1对下丘脑_腺垂体_肾上腺轴和海马的影响.pdfVIP

·138 · 国际内分泌代谢杂志2006 年 3 月第 26 卷第 2 期 　Intern J Endocrinol Metab ,March 2006 ,Vol 26 ,No . 2 β 11 HSD 1 对下丘脑 —腺垂体 —肾上腺轴 及海马的影响 欧杨 　李启富 ( ) β ( ) 　　【摘要】　糖皮质激素 GC 受 11 羟类固醇脱氢酶 HSD 1 的调节 ,对大脑活动产生广泛的影响 。 β 11 HSD1 催化无活性的 11脱氧皮质酮转化为有活性的 GC ,从而提高组织局部的 GC 浓度 ,加强 GC β 的作用 。GC 对下丘脑 —腺垂体 —肾上腺轴的负反馈调节作用受 11 HSD1 的影响 。海马是与认知 、 β 学习、记忆功能密切相关的重要脑区 ,极易受到随年龄增加的 GC 神经毒性的损伤 。11 HSD1 活性降 低有助于减轻与年龄相关的认知障碍 。 β 【关键词】　11 羟类固醇脱氢酶 Ⅰ型 ;海马 ;糖皮质激素 ;下丘脑 —垂体 —肾上腺轴 The effect of 11betahydroxysteroid dehydrogenase type 1 on hypothalamicpituitaryadrenal axis and hip pocampus 　OU Yang , LI Qif u. Dep artment of Endocrinology , The First Aff iliated Hosp ital , Chongqing Medical University , Chongqing 400016 , China 【Abstract 】　Glucocorticoids ( GC) affects a wide range of processes in the brain ,and is regulated by 11beta hydroxysteroid dehydrogenase type 1. 11betahydroxysteroid dehydrogenase type 1 catalyzes inert 11dehydrocorti costerone to its active glucocorticoids , elevates the concentration of glucocorticoids in the regional tissue and strengthens its effect . 11betahydroxysteroid dehydrogenase type 1 can influence the negative feedback action of glucocorticoids on the hypothalamicpituitaryadrenal axis. Hippocampus is an importanct encephalic region closely related to recognition ,learning ,memory , and is particularly vulnerable to the neurotoxicity of agerelated glucocorti coid. Reduction of the activity of 11betahydroxysteroid dehydrogenase type 1 can lessen agerelated cognitive im pairments. 【Key words】　11Betahydroxysteroid dehydrogenase type 1 ; Hippocampus ; Glucocorticoid ; Hypothalamic pituitaryadrenal axis (